Evidence map›Paper›PMID 33935045›Full record

ArticleMolecules and cells2021

Overexpression of COMP-Angiopoietin-1 in

Hyun-Jaung Sim, Min-Hye Kim, Govinda Bhattarai, Jae-Won Hwang, Han-Sol So, Sher Bahadur Poudel, Eui-Sic Cho, Sung-Ho Kook, Jeong-Chae Lee

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules and cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Hyun-Jaung SimCluster for Craniofacial Development and Regeneration Research, Institute of Oral Biosciences and School of Dentistry, Jeonbuk National University, Jeonju 54896, Korea.ORCID https://orcid.org/0000-0003-2189-7593
Min-Hye KimDepartment of Bioactive Material Sciences, Research Center of Bioactive Materials, Jeonbuk National University, Jeonju 54896, Korea.ORCID https://orcid.org/0000-0002-1366-7846
Govinda BhattaraiCluster for Craniofacial Development and Regeneration Research, Institute of Oral Biosciences and School of Dentistry, Jeonbuk National University, Jeonju 54896, Korea.ORCID https://orcid.org/0000-0002-3789-3442
Jae-Won HwangCluster for Craniofacial Development and Regeneration Research, Institute of Oral Biosciences and School of Dentistry, Jeonbuk National University, Jeonju 54896, Korea.ORCID https://orcid.org/0000-0002-5738-8187
Han-Sol SoDepartment of Bioactive Material Sciences, Research Center of Bioactive Materials, Jeonbuk National University, Jeonju 54896, Korea.ORCID https://orcid.org/0000-0003-0988-4685
Sher Bahadur PoudelDepartment of Basic Science & Craniofacial Biology, College of Dentistry, New York University, New York, NY 10010, USA.ORCID https://orcid.org/0000-0003-3733-4648
Eui-Sic ChoCluster for Craniofacial Development and Regeneration Research, Institute of Oral Biosciences and School of Dentistry, Jeonbuk National University, Jeonju 54896, Korea.ORCID https://orcid.org/0000-0002-7389-9817
Sung-Ho KookCluster for Craniofacial Development and Regeneration Research, Institute of Oral Biosciences and School of Dentistry, Jeonbuk National University, Jeonju 54896, Korea.ORCID https://orcid.org/0000-0002-1879-5927
Jeong-Chae LeeCluster for Craniofacial Development and Regeneration Research, Institute of Oral Biosciences and School of Dentistry, Jeonbuk National University, Jeonju 54896, Korea.ORCID https://orcid.org/0000-0002-4340-7965
Jeonbuk National University · KRNew York University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Numerous studies highlight the potential benefits potentials of supplemental cartilage oligomeric matrix protein-angiopoietin-1 (COMP-Ang1) through improved angiogenic effects. However, our recent findings show that excessive overexpression of COMP-Ang1 induces an impaired bone marrow (BM) microenvironment and senescence of hematopoietic stem cells (HSCs). Here, we investigated the underlying mechanisms of how excessive COMP-Ang1 affects the function of BM-conserved stem cells and hematopoiesis using

Indexed as

Angiopoietin-1AnimalsCell DifferentiationErythrocytesHematopoiesisHumansMiceMice, TransgenicAngiopoietin-1bone marrow-conserved stem cellscartilage oligomeric matrix protein-angiopoietin-1globin transcription factor 1stromal cell-derived factor 1/CXCR4 signaling axis

Identifiers

PMID33935045
PMCPMC8112173
OpenAlexW3158419643

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.