Evidence map›Paper›PMID 33934543›Full record

ArticleThoracic cancer2021

BAI1 nuclear expression reflects the survival of nonsmoking non-small cell lung cancer patients.

Hyo Jung An, Sung Hwan Kim, Jung Wook Yang, Min Hye Kim, Hye Jin Baek, Kyeong Hwa Ryu, Kyung Nyeo Jeon, Chang Sup Lee, Jun Young Choi, Dae Hyun Song

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thoracic cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Hyo Jung An *Department of Pathology, Gyeongsang National University Changwon Hospital, Changwon, South Korea.ORCID 0000-0002-2068-8370
Sung Hwan Kim *Department of Thoracic and Cardiovascular Surgery, Institute of Health Science, Gyeongsang National University Changwon Hospital, Gyeongsang National University College of Medicine, Jinju, South Korea.
Jung Wook YangDepartment of Pathology, Gyeongsang National University College of Medicine, Jinju, South Korea.
Min Hye KimDepartment of Pathology, Gyeongsang National University Hospital, Jinju, South Korea.
Hye Jin BaekDepartment of Radiology, Gyeongsang National University Changwon Hospital, Changwon, South Korea.
Kyeong Hwa RyuDepartment of Radiology, Gyeongsang National University Changwon Hospital, Changwon, South Korea.
Kyung Nyeo JeonDepartment of Radiology, Gyeongsang National University Changwon Hospital, Changwon, South Korea.
Chang Sup LeeCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju, South Korea.
Jun Young Choi *Department of Thoracic and Cardiovascular Surgery, Institute of Health Science, Gyeongsang National University Hospital, Gyeongsang National University College of Medicine, Jinju, South Korea.
Dae Hyun Song *Department of Pathology, Gyeongsang National University Changwon Hospital, Changwon, South Korea.ORCID 0000-0001-7163-0403
Changwon National University · KRGyeongsang National University Hospital · KRGyeongsang National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSmoking- and nonsmoking-associated lung cancers have different mechanisms of carcinogenesis. We divided non-small cell lung cancer (NSCLC) patients into nonsmoking and smoking groups with the aim of trying to understand the utility of brain-specific angiogenesis inhibitor 1 (BAI1) expression in the separate groups.

methodsClinicopathological data were obtained from 148 patients who had undergone surgery for NSCLC of the lung. Tissue microarray blocks were made of samples from NSCLC patients. Two pathologists graded the intensity of BAI1 expression as high or low expression in the cancer cells of patients in the smoking and nonsmoking groups.

resultsNSCLC nonsmokers with higher BAI1 nuclear expression had poor disease-specific survival (DSS) (hazard ratio: 2.679; 95% confidence interval [CI]:1.022-7.022, p = 0.045). The Kaplan-Meier survival curve confirmed that higher BAI1 expression was significantly associated with poor DSS (p = 0.034) in the nonsmoking group.

conclusionsWe divided NSCLC patients into nonsmoking and smoking groups and found that nuclear BAI1 expression was related to patient survival in nonsmoking NSCLC patients. We suggest BAI1 expression as a predictive marker of nonsmoking-associated NSCLC and recommend that it be evaluated as an AJCC staging criterion in the future.

Indexed as

AdultAgedAngiogenic ProteinsCarcinoma, Non-Small-Cell LungFemaleHumansLung NeoplasmsMaleMiddle AgedPrognosisReceptors, G-Protein-CoupledSmokingSurvival AnalysisADGRB1 protein, humanAngiogenic ProteinsReceptors, G-Protein-Coupledbrain-specific angiogenesis inhibitor 1non-small cell lung cancernonsmoking

Identifiers

PMID33934543
PMCPMC8169296
OpenAlexW3157946986

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.