ArticlePlant biotechnology journal2021
Molecular dissection of maize seedling salt tolerance using a genome-wide association analysis method.
Article in Plant biotechnology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 103 citations in OpenAlex.
- Biochemical Adaptations ofPlant-environment interactions (Hoboken, N.J.) · 2026Review
- Development of molecular markers associated with saline-alkali tolerance in rapeseed (Brassica napus L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Screening Key Genes for Salt Tolerance in Maize Inbred Lines via Time-Series Transcriptomics and Machine Learning.Plants (Basel, Switzerland) · 2026Article
- Artificial intelligence in plant salt stress research: from predictive models to multi-omics integration.Journal of experimental botany · 2026Review
- The incomplete dominance of gene expression controlled by Trans-eQTL hotspots contributes to heterosis in maize.Nature communications · 2026Article
- Genome wide association studies reveal candidate genes for salt tolerance in safflower (Frontiers in plant science · 2026Article
- A multi-locus genome-wide association study uncovers candidate genes for alkali tolerance in maize (Zea Mays L.) seedlings.BMC genomics · 2025Article
- Advances in deciphering the mechanisms of salt tolerance in Maize.Plant signaling & behavior · 2025Review
- Decades' progress and prospects on maize functional genomics and molecular breeding.Science China. Life sciences · 2025Review
- GWAS and gene co-expression network analysis reveal the genetic control of seed germination under salt stress in maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- High-resolution time-series transcriptomic and metabolomic profiling reveals the regulatory mechanism underlying salt tolerance in maize.Genome biology · 2025Article
- Root Transcriptome Analysis Identifies Salt-Tolerance Genes in Sweet Corn Chromosome Segment Substitution Lines (CSSLs).Plants (Basel, Switzerland) · 2025Article
- Integrating Genetic Diversity and Agronomic Innovations for Climate-Resilient Maize Systems.Plants (Basel, Switzerland) · 2025Review
- Single-cell transcriptomes reveal spatiotemporal heat stress response in maize roots.Nature communications · 2025Article
- CLC gene family inFrontiers in plant science · 2025Article
- CRISPR/Cas9: a sustainable technology to enhance climate resilience in major Staple Crops.Frontiers in genome editing · 2025Review
- Article
- Dynamic molecular regulation of salt stress responses in maize (Frontiers in plant science · 2025Article
- Comprehensive evaluation of maize germplasm for alkali tolerance during germination.Frontiers in plant science · 2025Article
- CRISPR/Cas9 mediated genome editing for crop improvement against Abiotic stresses: current trends and prospects.Functional & integrative genomics · 2024Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Salt stress is a major devastating abiotic factor that affects the yield and quality of maize. However, knowledge of the molecular mechanisms of the responses to salt stress in maize is limited. To elucidate the genetic basis of salt tolerance traits, a genome-wide association study was performed on 348 maize inbred lines under normal and salt stress conditions using 557 894 single nucleotide polymorphisms (SNPs). The phenotypic data for 27 traits revealed coefficients of variation of >25%. In total, 149 significant SNPs explaining 6.6%-11.2% of the phenotypic variation for each SNP were identified. Of the 104 identified quantitative trait loci (QTLs), 83 were related to salt tolerance and 21 to normal traits. Additionally, 13 QTLs were associated with two to five traits. Eleven and six QTLs controlling salt tolerance traits and normal root growth, respectively, co-localized with QTL intervals reported previously. Based on functional annotations, 13 candidate genes were predicted. Expression levels analysis of 12 candidate genes revealed that they were all responsive to salt stress. The CRISPR/Cas9 technology targeting three sites was applied in maize, and its editing efficiency reached 70%. By comparing the biomass of three CRISPR/Cas9 mutants of ZmCLCg and one zmpmp3 EMS mutant with their wild-type plants under salt stress, the salt tolerance function of candidate genes ZmCLCg and ZmPMP3 were confirmed. Chloride content analysis revealed that ZmCLCg regulated chloride transport under sodium chloride stress. These results help to explain genetic variations in salt tolerance and provide novel loci for generating salt-tolerant maize lines.
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