ArticleMolecular plant pathology2021
Mechanism of validamycin A inhibiting DON biosynthesis and synergizing with DMI fungicides against Fusarium graminearum.
Article in Molecular plant pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 39 citations in OpenAlex.
- Biocontrol Efficacy ofJournal of fungi (Basel, Switzerland) · 2026Article
- Recent advances in the biosynthetic mechanisms, regulation, and detoxification strategies of deoxynivalenol inFrontiers in nutrition · 2025Review
- Enhanced Antifungal Efficacy of Validamycin A Co-Administered withPlants (Basel, Switzerland) · 2024Article
- A smooth vetch (Frontiers in plant science · 2024Article
- Trehalase Inhibitor Validamycin May Have Additional Mechanisms of Toxicology againstJournal of fungi (Basel, Switzerland) · 2023Article
- Review
- Transcriptome Profile ofJournal of fungi (Basel, Switzerland) · 2022Article
- Genome of Paspalum vaginatum and the role of trehalose mediated autophagy in increasing maize biomass.Nature communications · 2022Article
- Deep-Sea Sediments from the Southern Gulf of Mexico Harbor a Wide Diversity of PKS I Genes.Antibiotics (Basel, Switzerland) · 2022Article
- The plasma membrane HMolecular plant pathology · 2022Article
- Linking Multi-Omics to Wheat Resistance Types toInternational journal of molecular sciences · 2022Review
- Potential biocontrol efficiency ofFrontiers in microbiology · 2022Article
- FgMet3 and FgMet14 related to cysteine and methionine biosynthesis regulate vegetative growth, sexual reproduction, pathogenicity, and sensitivity to fungicides inFrontiers in plant science · 2022Article
- Mechanism of validamycin A inhibiting DON biosynthesis and synergizing with DMI fungicides against Fusarium graminearum.Molecular plant pathology · 2021Article
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
Deoxynivalenol (DON) is a vital virulence factor of Fusarium graminearum, which causes Fusarium head blight (FHB). We recently found that validamycin A (VMA), an aminoglycoside antibiotic, can be used to control FHB and inhibit DON contamination, but its molecular mechanism is still unclear. In this study, we found that both neutral and acid trehalase (FgNTH and FgATH) are the targets of VMA in F. graminearum, and the deficiency of FgNTH and FgATH reduces the sensitivity to VMA by 2.12- and 1.79-fold, respectively, indicating that FgNTH is the main target of VMA. We found FgNTH is responsible for vegetative growth, FgATH is critical to sexual reproduction, and both of them play an important role in conidiation and virulence in F. graminearum. We found that FgNTH resided in the cytoplasm, affected the localization of FgATH, and positively regulated DON biosynthesis; however, FgATH resided in vacuole and negatively regulated DON biosynthesis. FgNTH interacted with FgPK (pyruvate kinase), a key enzyme in glycolysis, and the interaction was reduced by VMA; the deficiency of FgNTH affected the localization of FgPK under DON induction condition. Strains with a deficiency of FgNTH were more sensitive to demethylation inhibitor (DMI) fungicides. FgNTH regulated the expression level of FgCYP51A and FgCYP51B by interacting with FgCYP51B. Taken together, VMA inhibits DON biosynthesis by targeting FgNTH and reducing the interaction between FgNTH and FgPK, and synergizes with DMI fungicides against F. graminearum by decreasing FgCYP51A and FgCYP51B expression.
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