ArticleHuman brain mapping2021
Individual-based morphological brain network organization and its association with autistic symptoms in young children with autism spectrum disorder.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 36 citations in OpenAlex.
- Brain morphology network profiles in male and female youth with autism.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Bimodal social capital associated with psychosocial profiles and brain network topology in a Japanese population.Scientific reports · 2026Article
- Alteration of individual morphological brain networks in preschool children with autism spectrum disorder.Brain imaging and behavior · 2026Article
- Aberrant multivariate mapping between behavioral profiles and cortical morphological brain networks in children with autism spectrum disorder.Translational psychiatry · 2026Article
- Distance-related functional connectivity alterations in first-episode, drug-naïve major depressive disorder: a resting-state fMRI study with atlas-based neurotransmitter correlates.BMC psychiatry · 2026Article
- Correspondence between morphological similarity of the left lateral orbitofrontal cortex and neurotransmitter systems in adolescent males with autism.General psychiatry · 2026Article
- Study on the Topological Properties of Language Brain Region Networks in Children With Autism Based on Diffusion Tensor Imaging (DTI).Journal of autism and developmental disorders · 2026Article
- Neuroplasticity mechanisms of NDBIs in autism: a review from brain connectivity to behavioral improvement.European journal of medical research · 2026Review
- Combining functional, structural, and morphological networks for multimodal classification of developing autistic brains.Brain imaging and behavior · 2025Article
- Disruptions of morphological brain networks and their associations with multi-symptoms in children with spastic cerebral palsy.Quantitative imaging in medicine and surgery · 2025Article
- Effects of rTMS on swallowing function and neuroimaging features in post-stroke dysphagia.Frontiers in human neuroscience · 2025Article
- Longitudinal alterations in morphological brain networks and cognitive function in common-type COVID-19: a 3-month follow-up study.Frontiers in neurology · 2025Article
- Decreased Functional and Structural Connectivity is Associated with Core Symptom Improvement in Children with Autism Spectrum Disorder After Mini-basketball Training Program.Journal of autism and developmental disorders · 2024Article
- Brain functional gradient and structure features in adolescent and adult autism spectrum disorders.Human brain mapping · 2024Article
- Disrupted individual-level morphological brain network in spinal muscular atrophy types 2 and 3.CNS neuroscience & therapeutics · 2024Article
- Heterogeneity and convergence across seven neuroimaging modalities: a review of the autism spectrum disorder literature.Frontiers in psychiatry · 2024Review
- Individual-level brain morphological similarity networks: Current methodologies and applications.CNS neuroscience & therapeutics · 2023Review
- Unique Brain Network Identification Number for Parkinson's and Healthy Individuals Using Structural MRI.Brain sciences · 2023Article
- Social visual preference mediates the effect of cortical thickness on symptom severity in children with autism spectrum disorder.Frontiers in psychiatry · 2023Article
- Mapping brain functional and structural abnormities in autism spectrum disorder: moving toward precision treatment.Psychoradiology · 2022Review
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Individual-based morphological brain networks built from T1-weighted magnetic resonance imaging (MRI) reflect synchronous maturation intensities between anatomical regions at the individual level. Autism spectrum disorder (ASD) is a socio-cognitive and neurodevelopmental disorder with high neuroanatomical heterogeneity, but the specific patterns of morphological networks in ASD remain largely unexplored at the individual level. In this study, individual-based morphological networks were constructed by using high-resolution structural MRI data from 40 young children with ASD (age range: 2-8 years) and 38 age-, gender-, and handedness-matched typically developing children (TDC). Measurements were recorded as threefold. Results showed that compared with TDC, young children with ASD exhibited lower values of small-worldness (i.e., σ) of individual-level morphological brain networks, increased morphological connectivity in cortico-striatum-thalamic-cortical (CSTC) circuitry, and decreased morphological connectivity in the cortico-cortical network. In addition, morphological connectivity abnormalities can predict the severity of social communication deficits in young children with ASD, thus confirming an associational impact at the behavioral level. These findings suggest that the morphological brain network in the autistic developmental brain is inefficient in segregating and distributing information. The results also highlight the crucial role of abnormal morphological connectivity patterns in the socio-cognitive deficits of ASD and support the possible use of the aberrant developmental patterns of morphological brain networks in revealing new clinically-relevant biomarkers for ASD.
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