Observational studyAllergy2021
Prevalence and early-life risk factors of school-age allergic multimorbidity: The EuroPrevall-iFAAM birth cohort.
Observational study in Allergy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 3 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A systematic scoping review and gap analysis of questionnaires to assess multimorbidity among children.Pediatric research · 2026Pooled it
- The association between early-life respiratory infections and childhood asthma: a meta-analytic perspective.Frontiers in medicine · 2026Pooled it
- Cesarean section and the risk of allergic rhinitis in children: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- Thoracoabdominal Asynchrony in Healthy Children.Journal of sleep research · 2026Article
- Ultra-Processed Food Consumption and Childhood Allergic Diseases: Increased Risk of Asthma Onset in the SENDO Project.Allergy · 2026Article
- Association of atopic multimorbidity with childhood pet exposure and caesarean section delivery: a retrospective study from the Lifelines Cohort Study.Skin health and disease · 2026Article
- Review
- Early life factors and genetic interactions in allergic rhinitis: a genome-wide study.BMC pediatrics · 2026Article
- A synthetic bacterial community made of human milk isolated strains is an effective strategy to prevent food allergy in a mouse model.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Genetic Correlations and Causal Relationships Among Allergic Diseases: A Comprehensive Mendelian Randomization Study With Multiomic Mediation Analysis.Mediators of inflammation · 2026Article
- Asthma and Multi-Food Allergy Are Risk Factors for Oral Food Challenge Failure-A Single-Center Experience.Nutrients · 2025Article
- Allergic rhinitis and asthma: drivers of otitis media and associated tympanostomy tube placement.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Article
- Clinical Phenotypes of Severe Cow's Milk Protein Allergy with Various Responses to Amino Acid-Based Formula.Nutrients · 2025Observational
- Linking IgE and mast cells in pediatric allergic multimorbidity: omalizumab as a therapeutic strategy for asthma and cow's milk allergy.Central-European journal of immunology · 2025Article
- Allergen sensitization patterns: Allergic rhinitis with multimorbidity versus alone-A real-world study.Clinical and translational allergy · 2025Article
- Total IgE Trends in Children with Allergic Diseases.Journal of clinical medicine · 2024Article
- Association between environmental mercury exposure and allergic disorders in Korean children: Korean National Environmental Health Survey (KoNEHS) cycles 3-4 (2015-2020).Scientific reports · 2024Article
- Food allergies around the world.Frontiers in nutrition · 2024Review
- Risk factors of allergic rhinitis and its prevention strategies.Frontiers in allergy · 2024Review
- Early Prediction of Asthma.Journal of clinical medicine · 2023Review
Corrections and comments
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Authors and funding
28 authors.
Funding
Abstract
backgroundCoexistence of childhood asthma, eczema and allergic rhinitis is higher than can be expected by chance, suggesting a common mechanism. Data on allergic multimorbidity from a pan-European, population-based birth cohort study have been lacking. This study compares the prevalence and early-life risk factors of these diseases in European primary school children.
methodsIn the prospective multicentre observational EuroPrevall-iFAAM birth cohort study, we used standardized questionnaires on sociodemographics, medical history, parental allergies and lifestyle, and environmental exposures at birth, 12 and 24 months. At primary school age, parents answered ISAAC-based questions on current asthma, rhinitis and eczema. Allergic multimorbidity was defined as the coexistence of at least two of these.
resultsFrom 10,563 children recruited at birth in 8 study centres, we included data from 5,572 children (mean age 8.2 years; 51.8% boys). Prevalence estimates were as follows: asthma, 8.1%; allergic rhinitis, 13.3%; and eczema, 12.0%. Allergic multimorbidity was seen in 7.0% of the whole cohort, ranging from 1.2% (Athens, Greece) to 10.9% (Madrid, Spain). Risk factors for allergic multimorbidity, identified with AICc, included family-allergy-score, odds ratio (OR) 1.50 (95% CI 1.32-1.70) per standard deviation; early-life allergy symptoms, OR 2.72 (2.34-3.16) for each symptom; and caesarean birth, OR 1.35 (1.04-1.76). Female gender, OR 0.72 (0.58-0.90); older siblings, OR 0.79 (0.63-0.99); and day care, OR 0.81 (0.63-1.06) were protective factors.
conclusionAllergic multimorbidity should be regarded as an important chronic childhood disease in Europe. Some of the associated early-life factors are modifiable and may be considered for prevention strategies.
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