Evidence map›Paper›PMID 33934313›Full record

ArticleInternational journal of computer assisted radiology and surgery2021

Generation of annotated multimodal ground truth datasets for abdominal medical image registration.

Dominik F Bauer, Tom Russ, Barbara I Waldkirch, Christian Tönnes, William P Segars, Lothar R Schad, Frank G Zöllner, Alena-Kathrin Golla

Open access · hybridAbstract read
In one paragraph

Article in International journal of computer assisted radiology and surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Unsupervised segmentation of dynamic pulmonary MRI using cross-modality adaptation with annotated CT images.International journal of computer assisted radiology and surgery · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Dominik F BauerComputer Assisted Clinical Medicine, Mannheim Institute for Intelligent Systems in Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. dominik.bauer@medma.uni-heidelberg.de.ORCID http://orcid.org/0000-0002-8781-2882
Tom RussComputer Assisted Clinical Medicine, Mannheim Institute for Intelligent Systems in Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Barbara I WaldkirchComputer Assisted Clinical Medicine, Mannheim Institute for Intelligent Systems in Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Christian TönnesComputer Assisted Clinical Medicine, Mannheim Institute for Intelligent Systems in Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
William P SegarsCarl E. Ravin Advanced Imaging Labs, Department of Radiology, Duke University, Durham, USA.
Lothar R SchadComputer Assisted Clinical Medicine, Mannheim Institute for Intelligent Systems in Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Frank G ZöllnerComputer Assisted Clinical Medicine, Mannheim Institute for Intelligent Systems in Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Alena-Kathrin GollaComputer Assisted Clinical Medicine, Mannheim Institute for Intelligent Systems in Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Heidelberg University · DEDuke University · USUniversity of Mannheim · DE

Funding

TR&D Project 3: Virtual ReadersP41EB028744 · NIBIB · DUKE UNIVERSITY · PI Ehsan Samei · 2021 to 2026
$7.8M
Toward precision radiotherapy: Physiological modeling of respiratory motion based on ultra-quality 4D-MRIR01CA226899 · NCI · UNIVERSITY OF VIRGINIA · PI CAI, JING, MILLER, G. WILSON · 2019 to 2023
$2.2M
Bundesministerium für Bildung und Forschung 13GW0388ANCI NIH HHS R01 CA226899NIBIB NIH HHS P41 EB028744
6 · The paper itself

Abstract

purposeSparsity of annotated data is a major limitation in medical image processing tasks such as registration. Registered multimodal image data are essential for the diagnosis of medical conditions and the success of interventional medical procedures. To overcome the shortage of data, we present a method that allows the generation of annotated multimodal 4D datasets.

methodsWe use a CycleGAN network architecture to generate multimodal synthetic data from the 4D extended cardiac-torso (XCAT) phantom and real patient data. Organ masks are provided by the XCAT phantom; therefore, the generated dataset can serve as ground truth for image segmentation and registration. Realistic simulation of respiration and heartbeat is possible within the XCAT framework. To underline the usability as a registration ground truth, a proof of principle registration is performed.

resultsCompared to real patient data, the synthetic data showed good agreement regarding the image voxel intensity distribution and the noise characteristics. The generated T1-weighted magnetic resonance imaging, computed tomography (CT), and cone beam CT images are inherently co-registered. Thus, the synthetic dataset allowed us to optimize registration parameters of a multimodal non-rigid registration, utilizing liver organ masks for evaluation.

conclusionOur proposed framework provides not only annotated but also multimodal synthetic data which can serve as a ground truth for various tasks in medical imaging processing. We demonstrated the applicability of synthetic data for the development of multimodal medical image registration algorithms.

Indexed as

AlgorithmsComputer SimulationPhantoms, ImagingCone-Beam Computed TomographyHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingCycleGANImage registrationImage synthesisLiverMultimodal imaging

Identifiers

PMID33934313
PMCPMC8295129
OpenAlexW3157427666

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.