Evidence map›Paper›PMID 33934306›Full record

ArticleEnvironmental science and pollution research international2021

In silico screening of potent bioactive compounds from honeybee products against COVID-19 target enzymes.

Moataz A Shaldam, Galal Yahya, Nashwa H Mohamed, Mohamed M Abdel-Daim, Yahya Al Naggar

Open access · bronzeAbstract read
In one paragraph

Article in Environmental science and pollution research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Natural Products as a Potential Source of Promising Therapeutics for COVID-19 and Viral Diseases.Evidence-based complementary and alternative medicine : eCAM · 2023
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 3 countries.

Moataz A ShaldamDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafr EL Sheikh University, Kafr El Sheikh, 33516, Egypt.
Galal YahyaMicrobiology and Immunology Department, Faculty of Pharmacy, Zagazig University, Al Sharqia, 44519, Egypt.
Nashwa H MohamedHospitals of Zagazig University, Al Sharqia, Egypt.
Mohamed M Abdel-DaimDepartment of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Yahya Al NaggarZoology Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt. yehia.elnagar@science.tanta.edu.eg.ORCID http://orcid.org/0000-0002-8111-918X
Kafrelsheikh University · EGSuez Canal University · EGTanta University · EGUniversity of Kaiserslautern · DEZagazig University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

After the early advent of the Coronavirus Disease 2019 (COVID-19) pandemic, myriads of FDA-approved drugs have been massively repurposed for COVID-19 treatment based on molecular docking against selected protein targets that play fundamental roles in the replication cycle of the novel coronavirus. Honeybee products are well known of their nutritional values and medicinal effects. Bee products contain bioactive compounds in the form of a collection of phenolic acids, flavonoids, and terpenes of natural origin that display wide spectrum antiviral effects. We revealed by molecular docking the profound binding affinity of 14 selected phenolics and terpenes present in honey and propolis (bees glue) against the main protease (M

Indexed as

Coronavirus InfectionsCOVID-19 Drug TreatmentAnimalsAntiviral AgentsBeesHumansMolecular Docking SimulationSARS-CoV-2Antiviral AgentsCOVID-19Drug repurposingHoneybee productsMolecular dockingNatural productsPhenolic compounds

Identifiers

PMID33934306
PMCPMC8088405
OpenAlexW3090445006

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.