ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2021
Plant-derived bioactive compounds produced by Streptomyces variabilis LCP18 associated with Litsea cubeba (Lour.) Pers as potential target to combat human pathogenic bacteria and human cancer cell lines.
Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 21 citations in OpenAlex.
- Sponge-Derived Streptomyces variabilis Extract Modulates Host Immune Gene Expression and Improves Survival in Caenorhabditis elegans During Vibrio parahaemolyticus Infection.Current microbiology · 2026Article
- Unlocking the microbial treasure trove: advances in Streptomyces derived secondary metabolites in the battle against cancer.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Antiproliferative activities of phytochemicals isolated from the leaves of Dolichos kilimandischaricus (Harms) ex Taub. (Fabaceae) on Jurkat and HL-60 leukemic cells.BMC complementary medicine and therapies · 2025Article
- Antitumor Activity, Mechanisms of Action and Phytochemical Profiling of Sub-Fractions Obtained fromMolecules (Basel, Switzerland) · 2025Article
- Bioactivity and metabolic profiling of crude extracts from endophytic bacteria linked toHeliyon · 2025Article
- An Overview of Lsr2 Repressor Effect inMicroorganisms · 2024Article
- Metabolic and genomic analysis deciphering biocontrol potential of endophytic Streptomyces albus RC2 against crop pathogenic fungi.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Screening for chitin degrading bacteria in the environment of Saudi Arabia and characterization of the most potent chitinase from Streptomyces variabilis Am1.Scientific reports · 2023Article
- The Volatile Organic Compounds ofMicroorganisms · 2023Article
- Overexpression ofForestry research · 2023Article
- Genome-Guided Investigation Provides New Insights into Secondary Metabolites ofPolish journal of microbiology · 2022Article
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To date, endophytic actinomycetes have been well-documented as great producers of novel antibiotics and important pharmaceutical leads. The present study aimed to evaluate potent bioactivities of metabolites synthesized by the strain LCP18 residing in the Vietnamese medicinal plant Litsea cubeba (Lour.) Pers towards human pathogenic bacteria and human cancer cell lines. Endophytic actinomycete strain LCP18 showed considerable inhibition against seven bacterial pathogens and three human tumor cell lines and was identified as species Streptomyces variabilis. Strain S. variabilis LCP18 was phenotypically resistant to fosfomycin, trimethoprim-sulfamethoxazole, dalacin, cefoxitin, rifampicin, and fusidic acid and harbored the two antibiotic biosynthetic genes such as PKS-II and NRPS. Further purification and structural elucidation of metabolites from the LCP18 extract revealed five plant-derived bioactive compounds including isopcrunetin, genistein, daidzein, syringic acid, and daucosterol. Among those, isoprunetin, genistein, and daidzein exhibited antibacterial activity against Salmonella typhimurium ATCC 14,028 and methicillin-resistant Staphylococcus epidermidis ATCC 35,984 with the MIC values ranging from 16 to 128 µg/ml. These plant-derived compounds also exhibited cytotoxic effects against human lung cancer cell line A549 with IC
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