Evidence map›Paper›PMID 33934254›Full record

ArticleDigestive diseases and sciences2022

Gastrointestinal Computed Tomography Findings in Chronic Granulomatous Disease with Subgroup Clinicopathologic Analysis.

Sumona Bhattacharya, Yilun Koethe, Alexander Ling, Natasha Kamal, Sajneet Khangura, Meghna Alimchandani, Martha M Quezado, Christa S Zerbe, Harry L Malech, John I Gallin and 4 more

Abstract read
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In one paragraph

Article in Digestive diseases and sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Sumona BhattacharyaDigestive Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Dr., Room 5-2740, Bethesda, MD, 20892, USA.
Yilun KoetheMiami Cardiac and Vascular Institute, 8900 N. Kendal Drive, Miami, FL, 33176, USA.
Alexander LingRadiology and Imaging Sciences, National Institutes of Health, 10 Center Dr., MSC 1182, Bethesda, MD, 20892, USA.
Natasha KamalDivision of Gastroenterology, University of Maryland School of Medicine, 22 South Greene St, N3W156, Baltimore, MD, 21201, USA.
Sajneet KhanguraGastroenterology Consultants of San Antonio, 11211 State Hwy 151, Medical Plaza 1, Ste. 250, San Antonio, TX, 78251, USA.
Meghna AlimchandaniLaboratory of Pathology, National Cancer Institute, National Institutes of Health, 10 Center Dr., Magnuson CC, Room 2A10, Bethesda, MD, 20892, USA.
Martha M QuezadoLaboratory of Pathology, National Cancer Institute, National Institutes of Health, 10 Center Dr., Magnuson CC, Room 2A10, Bethesda, MD, 20892, USA.
Christa S ZerbeLaboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Dr., MSC 1460, Bethesda, MD, 20892, USA.
Harry L MalechLaboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Dr., Rm 5-3750, MSC 1456, Bethesda, MD, 20892, USA.
John I GallinClinical Pathophysiology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Dr., Room 6-2551, Bethesda, MD, 20892, USA.
Steven M HollandLaboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, CRC B3 4141 MSC 1684, Bethesda, MD, 20892, USA.
Theo HellerTranslational Hepatology Unit, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 Center Dr., Building 10, Room 9C432B, 10 Center Dr., Bethesda, MD, 20814, USA.
Elizabeth JonesRadiology and Imaging Sciences, Clinical Center, National Institutes of Health, 10 Center Dr., Building 10, MSC 1182, Bethesda, MD, 20892, USA.
Aradhana M VenkatesanAbdominal Imaging, Division of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. avenkatesan@mdanderson.org.ORCID 0000-0002-5033-0820
National Institutes of Health · USNational Institutes of Health Clinical Center · USThe Cardiac and Vascular Institute · USThe University of Texas MD Anderson Cancer Center · USUniversity of Maryland, Baltimore · US

Funding

Gene Therapy Basic Research to Treat Inherited Primary Immune DeficienciesZIAAI000644 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MALECH, HARRY L · 2009 to 2025
$12.1M
Investigation of non-cirrhotic portal hypertension.ZIADK075008 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI HELLER, THEO · 2009 to 2025
$4.5M
Clinical Studies Of Abnormal Host DefenseZIAAI000155 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GALLIN, JOHN I · 2009 to 2022
$3.1M
6 · The paper itself

Abstract

backgroundChronic granulomatous disease (CGD) is a rare primary immunodeficiency which can lead to gastrointestinal (GI) complications including inflammatory bowel disease. Radiographic findings in this cohort have not been well described.

aimsTo describe the frequency and spectrum of gastrointestinal abnormalities seen on computed tomography (CT) in patients with CGD and determine whether radiography was predictive of endoscopic or histopathologic inflammatory findings.

methodsA retrospective review was conducted on 141 consecutive CGD patients seen at the National Institutes of Health between 1988 and 2011. All corresponding CTs were reviewed for gastrointestinal abnormalities including wall thickening. Endoscopic and histopathologic findings were reviewed in subjects with documented endoscopy within 30 days of an imaging study. Findings were compared between patients with and without wall thickening on CT to determine whether bowel wall thickening was predictive of endoscopic or histologic inflammatory findings.

resultsTwo hundred and ninety-two CTs were reviewed. GI wall thickening was present on CT in 61% of patients (n = 86). Among a subgroup of 20 patients who underwent endoscopy at the time of their imaging, there was a statistically significant correlation between radiographic gastrointestinal wall thickening and endoscopic inflammation in the same intestinal segment (p = 0.035). Additionally, there was a significant correlation between radiographic gastrointestinal wall thickening and inflammatory features on histopathology (p = 0.02).

conclusionsGI abnormalities are commonly observed on CT in CGD patients. Bowel wall thickening correlates with endoscopic and histopathologic evidence of inflammation. These findings may be used to better facilitate directed endoscopic assessment and histopathologic sampling in patients with CGD.

Indexed as

Gastrointestinal DiseasesGranulomatous Disease, ChronicEndoscopy, GastrointestinalHumansInflammationRetrospective StudiesTomography, X-Ray ComputedCGD colitisChronic granulomatous diseaseInflammatory bowel diseaseRadiography

Identifiers

PMID33934254
OpenAlexW3158085831

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.