Evidence map›Paper›PMID 33934225›Full record

ArticlePflugers Archiv : European journal of physiology2021

A detailed characterization of the hyperpolarization-activated "funny" current (I

Federica Giannetti, Patrizia Benzoni, Giulia Campostrini, Raffaella Milanesi, Annalisa Bucchi, Mirko Baruscotti, Patrizia Dell'Era, Alessandra Rossini, Andrea Barbuti

Open access · hybridAbstract read
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Intracellular CaInternational journal of molecular sciences · 2026
    Article
  4. Fluorescence-lifetime optical electrophysiology in contracting cardiomyocytes.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
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  7. Review
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  9. Article
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  12. Circulation. Arrhythmia and electrophysiology · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Biophysical properties of NaScientific reports · 2023
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Federica Giannetti *The Cell Physiology MiLab, Department of Biosciences, Università degli Studi di Milano, Via Celoria 26, 20133, Milano, Italy.ORCID 0000-0002-1785-5529
Patrizia Benzoni *The Cell Physiology MiLab, Department of Biosciences, Università degli Studi di Milano, Via Celoria 26, 20133, Milano, Italy.ORCID 0000-0002-3371-3301
Giulia CampostriniThe Cell Physiology MiLab, Department of Biosciences, Università degli Studi di Milano, Via Celoria 26, 20133, Milano, Italy.ORCID 0000-0003-4688-4991
Raffaella MilanesiThe Cell Physiology MiLab, Department of Biosciences, Università degli Studi di Milano, Via Celoria 26, 20133, Milano, Italy.ORCID 0000-0001-9513-8878
Annalisa BucchiThe Cell Physiology MiLab, Department of Biosciences, Università degli Studi di Milano, Via Celoria 26, 20133, Milano, Italy.ORCID 0000-0002-5303-4242
Mirko BaruscottiThe Cell Physiology MiLab, Department of Biosciences, Università degli Studi di Milano, Via Celoria 26, 20133, Milano, Italy.ORCID 0000-0002-6155-8388
Patrizia Dell'EraCellular Fate Reprogramming Unit, Department of Molecular and Translational Medicine, University of Brescia, viale Europa 11, 25123, Brescia, Italy.ORCID 0000-0001-6682-6321
Alessandra RossiniInstitute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Viale Druso 1, 39100, Bolzano, Italy.ORCID 0000-0002-0440-1130
Andrea BarbutiThe Cell Physiology MiLab, Department of Biosciences, Università degli Studi di Milano, Via Celoria 26, 20133, Milano, Italy. andrea.barbuti@unimi.it.ORCID 0000-0002-4521-4913
University of Milan · ITEurac Research · ITUniversity of Brescia · IT

Funding

Fondazione Cariplo 2014-0822Fondazione Cariplo 2014-1090
6 · The paper itself

Abstract

Properties of the funny current (I

Indexed as

Action PotentialsBiological ClocksCell DifferentiationCell LineElectrophysiologyHeart AtriaHumansHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsInduced Pluripotent Stem CellsIsoproterenolMyocytes, CardiacPatch-Clamp TechniquesSinoatrial NodeHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsIsoproterenolFunny currentHCN channelsHuman-induced pluripotent stem cells (hiPSC)PacemakerSinus node

Identifiers

PMID33934225
PMCPMC8245366
OpenAlexW3158662282

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.