Evidence map›Paper›PMID 33934222›Full record

ArticleAmino acids2021

Solid-phase synthesis of D-fructose-derived Heyns peptides utilizing N

Sebastian Schmutzler, Daniel Knappe, Andreas Marx, Ralf Hoffmann

Open access · hybridAbstract read
In one paragraph

Article in Amino acids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Synthesis of ZIF-8 Coated MnOCurrent microbiology · 2025
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Sebastian SchmutzlerInstitut Für Bioanalytische Chemie, Fakultät Für Chemie Und Mineralogie, Universität Leipzig, Leipzig, Germany.
Daniel KnappeInstitut Für Bioanalytische Chemie, Fakultät Für Chemie Und Mineralogie, Universität Leipzig, Leipzig, Germany.
Andreas MarxSite Management - Analytics, Merck KGaA, Darmstadt, Germany.
Ralf HoffmannInstitut Für Bioanalytische Chemie, Fakultät Für Chemie Und Mineralogie, Universität Leipzig, Leipzig, Germany. bioanaly@rz.uni-leipzig.de.ORCID http://orcid.org/0000-0001-9932-5646
Leipzig University · DEMerck (Germany) · DENeurologisches Rehabilitationszentrum Leipzig · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aldoses and ketoses can glycate proteins yielding isomeric Amadori and Heyns products, respectively. Evidently, D-fructose is more involved in glycoxidation than D-glucose favoring the formation of advanced glycation endproducts (AGEs). While Amadori products and glucation have been studied extensively, the in vivo effects of fructation are largely unknown. The characterization of isomeric Amadori and Heyns peptides requires sufficient quantities of pure peptides. Thus, the glycated building block N

Indexed as

Solid-Phase Synthesis TechniquesPeptidesPeptidesFructoseGlycationHeyns compoundMaillard reactionNε-glucosyllysin building blockSolid-phase peptide synthesis (SPPS)

Identifiers

PMID33934222
PMCPMC8172402
OpenAlexW3157093422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.