ArticleJournal of neurology2021
ASPECTS-based net water uptake as an imaging biomarker for lesion age in acute ischemic stroke.
Article in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Mediation of ghost infarct core on prognosis by venous outflow and net water uptake after stroke thrombectomy.European radiology · 2026Article
- Machine learning models for CT-based classification of ischemic stroke onset time within or beyond 4.5 h: a comparison of approaches.European radiology · 2026Article
- Net water uptake as a predictor of the development of high-density lesions after endovascular treatment.Neuroradiology · 2026Article
- Location-Specific Net Water Uptake and Malignant Cerebral Edema in Acute Anterior Circulation Occlusion Ischemic Stroke.AJNR. American journal of neuroradiology · 2025Article
- Predictive value of net water uptake for early neurological deterioration after mechanical thrombectomy in acute ischemic stroke with large vessel occlusion.Frontiers in neurology · 2025Article
- Current perspective in acute ischemic stroke: net water uptake and imaging-guided selection as bridges to personalized, tissue-based care.Frontiers in neurology · 2025Article
- Deep learning biomarker of chronometric and biological ischemic stroke lesion age from unenhanced CT.NPJ digital medicine · 2024Article
- A dual-energy computed tomography-based radiomics nomogram for predicting time since stroke onset: a multicenter study.European radiology · 2024Article
- Association between occlusion location, net water uptake and ischemic lesion growth in large vessel anterior circulation strokes.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Novel advanced imaging techniques for cerebral oedema.Frontiers in neurology · 2024Review
- Automated Estimation of Quantitative Lesion Water Uptake as a Prognostic Biomarker for Patients with Ischemic Stroke and Large-Vessel Occlusion.AJNR. American journal of neuroradiology · 2023Article
- Automated Measurement of Net Water Uptake From Baseline and Follow-Up CTs in Patients With Large Vessel Occlusion Stroke.Frontiers in neurology · 2022Article
- Value of Multimodal Computed Tomography Quantitative Analysis for Predicting Early Neurological Deterioration in Acute Ischemic Stroke Patients Undergoing Intravenous Thrombolysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
Abstract
objectiveWe assessed the value of computed tomography (CT) and automated Alberta Stroke Program Early CT Score (ASPECTS) with net water uptake (NWU) to predict stroke onset time.
methodsTwo-hundred forty stroke patients with anterior circulation large-vessel occlusion were included. CT-ASPECTS-NWU values were calculated by comparing the mean Hounsfield units of affected ASPECTS regions with unaffected contralateral regions. The correlation between ASPECTS-NWU and stroke onset to CT time was assessed. ASPECTS-NWU predictive values were calculated to identify a stroke onset to CT time of within 4.5/6 h.
resultsA correlation existed between stroke onset to CT time and ASPECTS-NWU (r = 0.65, p < 0.001), which was affected by collateral status and infarct location. The area under the receiver operating characteristic (ROC) curve (AUC) for distinguishing a stroke onset to CT time of within 4.5 h was 0.837 (95% confidence interval [CI] 0.784-0.881; optimal cutoff 7%; sensitivity 87.10%; specificity 62.36%). The multi-index AUC was 0.884 (95% CI 0.837-0.922). The AUC for distinguishing a stroke onset to CT time of within 6 h was 0.836 (95% CI 0.783-0.880; optimal cutoff 9%; sensitivity 72.73%; specificity 81.16%). The multi-index AUC was 0.881 (95% CI 0.834-0.920).
conclusionsASPECTS-NWU may be used to determine stroke onset time in patients with unwitnessed or wake-up stroke.
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Registered trials
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