Trial reportPediatric research2022
Brain functional connectivity in children with developmental coordination disorder following rehabilitation intervention.
Trial report in Pediatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The prevalence of developmental coordination disorder in children: a systematic review and meta-analysis.Frontiers in pediatrics · 2024Pooled it
- Behavioral and Neuroimaging Research on Developmental Coordination Disorder (DCD): A Combined Systematic Review and Meta-Analysis of Recent Findings.Frontiers in psychology · 2022Pooled it
- Functional connectivity during tic suppression predicts reductions in vocal tics following behavior therapy in children with Tourette syndrome.Psychological medicine · 2023Trial
- Effectiveness of Cognitive Orientation to Occupational Performance intervention in improving motor skills of children with developmental coordination disorder: A randomized waitlist-control trial.Clinical rehabilitation · 2022Trial
- Implementing the Cognitive Orientation to Daily Occupational Performance (CO-OP) Approach with Children with Fetal Alcohol Spectrum Disorder: A Feasibility Study.Children (Basel, Switzerland) · 2026Article
- Artificial Intelligence in the Evaluation and Intervention of Developmental Coordination Disorder: A Scoping Review of Methods, Clinical Purposes, and Future Directions.Children (Basel, Switzerland) · 2026Review
- Motor intervention therapy for children with developmental coordination disorder: from behavioral improvement to neuroplasticity mechanisms.Frontiers in human neuroscience · 2026Review
- Association between Motor Skills, Occupational Performance, and Mental Health in Japanese Children with Neurodevelopmental Disorders: A Cross-Sectional Correlational Study.Children (Basel, Switzerland) · 2024Article
- Review of the Brain's Behaviour after Injury and Disease for Its Application in an Agent-Based Model (ABM).Biomimetics (Basel, Switzerland) · 2024Review
- Changes in cortical grey matter volume with Cognitive Orientation to daily Occupational Performance intervention in children with developmental coordination disorder.Frontiers in human neuroscience · 2024Article
- A systematic review of behavioral and neurobiological profiles associated with coexisting attention-deficit/hyperactivity disorder and developmental coordination disorder.Neuroscience and biobehavioral reviews · 2023Review
- Effectiveness of CO-OP Approach for Children With Neurodevelopmental Disorders: A Systematic Review.Archives of rehabilitation research and clinical translation · 2023Review
- Cognitive Orientation to Daily Occupational Performance: A Randomized Controlled Trial Examining Intervention Effects on Children with Developmental Coordination Disorder Traits.Brain sciences · 2023Article
- Motor learning in developmental coordination disorder: behavioral and neuroimaging study.Frontiers in neuroscience · 2023Article
- Perspective: Acknowledging complexity to advance the understanding of developmental coordination disorder.Frontiers in human neuroscience · 2022Article
- White Matter Changes With Rehabilitation in Children With Developmental Coordination Disorder: A Randomized Controlled Trial.Frontiers in human neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundChildren with developmental coordination disorder (DCD) show improved motor function after Cognitive Orientation to Occupational Performance (CO-OP) intervention; however, the neural basis for these improvements is unknown.
methodsIn this randomized waitlist-controlled trial, 78 children with DCD (with/without ADHD) were randomly assigned to either a treatment or waitlist group and underwent three resting-state MRI scans over six months. The treatment group received intervention between the first and second scan; the waitlist group received intervention between the second and third scan.
resultsAfter CO-OP intervention, children with DCD [13 male, 8 female; mean (SD) age: 10.0 (1.7) years] showed increased functional connectivity between the default mode network and right anterior cingulate gyrus (p < 0.01). Additional gains were noted at follow-up three months after the intervention, with greater functional connectivity between the dorsal attention network and precentral gyrus (p < 0.02). However, children with DCD + ADHD [18 male, 1 female; mean (SD) age: 10.0 (1.14) years] did not show brain changes following CO-OP.
conclusionFor children with DCD, increased functional connectivity in networks associated with self-, emotion-, and attention-regulation may underlie motor skill improvements observed after CO-OP intervention. Modifications to the CO-OP protocol may be required to induce similar brain changes in children with DCD + ADHD. IMPACT: This study provides neuroscientific evidence for the Cognitive Orientation to Occupational Performance (CO-OP) approach as an effective rehabilitation intervention to induce brain and behavioral changes in children with DCD. While children with DCD ± ADHD showed improved motor function after CO-OP, only children with DCD showed brain changes after intervention. Children with DCD showed increased functional connectivity in networks associated with self-, emotion-, and attention-regulation after the intervention. Treatment modifications may be required to induce similar brain changes in children with DCD + ADHD. Pediatricians are encouraged to refer children with DCD with and without ADHD for CO-OP intervention to improve their motor skills.
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