Evidence map›Paper›PMID 33934096›Full record

ReviewActa cytologica2021

Digital/Computational Technology for Molecular Cytology Testing: A Short Technical Note with Literature Review.

Robert Y Osamura, Naruaki Matsui, Masato Kawashima, Hiroyasu Saiga, Maki Ogura, Tomoharu Kiyuna

Open access · hybridAbstract readReview
In one paragraph

Review in Acta cytologica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Robert Y OsamuraDepartment of Diagnostic Pathology Nippon Koukan Hospital, Kawasaki, Japan.
Naruaki MatsuiDepartment of Diagnostic Pathology Nippon Koukan Hospital, Kawasaki, Japan.
Masato KawashimaDepartment of Diagnostic Pathology Nippon Koukan Hospital, Kawasaki, Japan.
Hiroyasu SaigaDigital Healthcare Business Development Office, NEC Corp, Tokyo, Japan.
Maki OguraDigital Healthcare Business Development Office, NEC Corp, Tokyo, Japan.
Tomoharu KiyunaDigital Healthcare Business Development Office, NEC Corp, Tokyo, Japan.
NEC (Japan) · JPKeio University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This short article describes the method of digital cytopathology using Z-stack scanning with or without extended focusing. This technology is suitable to observe such thick clusters as adenocarcinoma on cytologic specimens. Artificial intelligence (AI) has been applied to histological images, but its application on cytologic images is still limited. This article describes our attempt to apply AI technology to cytologic digital images. For molecular analysis, cytologic materials, such as smear, LBC, and cell blocks, have been successfully used for targeted single gene detection and multiplex gene analysis with next-generation sequencing. As a future perspective, the system can be connected to full automation by combining digital cytopathology with AI application to detect target cancer cells and to perform molecular analysis. The literature review is updated according to the subjects.

Indexed as

Artificial IntelligenceDiagnosis, Computer-AssistedImage Processing, Computer-AssistedMolecular Diagnostic TechniquesPathology, MolecularAdenocarcinoma of LungAutomation, LaboratoryDNA Mutational AnalysisErbB ReceptorsHumansLung NeoplasmsMutationPredictive Value of TestsReproducibility of ResultsEGFR protein, humanErbB ReceptorsArtificial intelligenceDigital cytopathologyMolecular cytopathology

Identifiers

PMID33934096
PMCPMC8491512
OpenAlexW3157410828

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.