Evidence map›Paper›PMID 33933921›Full record

Trial reportGeneral hospital psychiatry

Economic outcomes of depression screening after acute coronary syndromes: The CODIACS-QoL randomized clinical trial.

Joseph A Ladapo, Karina W Davidson, Nathalie Moise, Alexander Chen, Gregory N Clarke, Rowena J Dolor, Karen L Margolis, Anusorn Thanataveerat, Ian M Kronish

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in General hospital psychiatry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01993017 (Depression Screening RCT in ACS Patients), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01993017 nacompletednot on this map

Depression Screening RCT in ACS Patients: Quality of Life and Cost Outcomes

TypeinterventionalSponsorColumbia UniversityRan2013 to 2019Enrolled1,501ConditionsAcute Coronary Syndrome, Depressive SymptomsArmsCognitive Behavioral Therapy (CBT), Antidepressant Medication, Standard Care, Depressive symptom screener, No intervention
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Joseph A LadapoDavid Geffen School of Medicine at UCLA, Los Angeles, CA, United States of America. Electronic address: jladapo@mednet.ucla.edu.
Karina W DavidsonCenter for Personalized Health, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, United States of America.
Nathalie MoiseColumbia University Irving Medical Center, New York, NY, United States of America.
Alexander ChenDavid Geffen School of Medicine at UCLA, Los Angeles, CA, United States of America.
Gregory N ClarkeKaiser Permanente, Portland, OR, United States of America.
Rowena J DolorDuke University School of Medicine, Durham, NC, United States of America.
Karen L MargolisHealthPartners Institute, Minneapolis, MN, United States of America.
Anusorn ThanataveeratColumbia University Irving Medical Center, New York, NY, United States of America.
Ian M KronishColumbia University Irving Medical Center, New York, NY, United States of America.
Columbia University Irving Medical Center · USUniversity of California, Los Angeles · USDuke University · USFeinstein Institute for Medical Research · USHealthPartners · USKaiser Permanente · US

Funding

Depression Screening RCT in ACS patients: Quality of Life and Cost OutcomesR01HL114924 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KRONISH, IAN MATTHEW · 2013 to 2017
$4.2M
Financial incentive strategies for smoking cessation in high-risk, hospitalized patients.R01DA045688 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LADAPO, JOSEPH ABIODUN, SHERMAN, SCOTT E · 2019 to 2023
$3.8M
Financial incentive strategies for weight loss in obese patients living in socioeconomically disadvantaged neighborhoodsR01MD011544 · NIMHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JAY, MELANIE, WALI, SOMA · 2016 to 2020
$3.5M
Behavioral Economics and Implementation Research to Reduce Cardiovascular Risk in HIV-infected AdultsU01HL142104 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DIAMANT, ALLISON LESLIE · 2018 to 2021
$2.7M
NHLBI NIH HHS R01 HL114924NHLBI NIH HHS U01 HL142104NIDA NIH HHS R01 DA045688NIMHD NIH HHS R01 MD011544
6 · The paper itself

Abstract

objectiveTo evaluate the cost-effectiveness of screening for depression in patients with acute coronary syndrome (ACS) and no history of depression.

methodsCost-effectiveness analysis of a randomized trial enrolling 1500 patients with ACS between 2013 and 2017. Patients were randomized to no screening, screening and notifying the primary care provider (PCP), and screening, notifying the PCP, and providing enhanced depression treatment. Outcomes measured were Healthcare utilization, costs, and incremental cost-effectiveness ratios.

results7.1% of patients screened positive for depressive symptoms. There was no significant difference in usage of mental health services, cardiovascular tests and procedures, and medications. Mean total costs in No Screen group ($7440), in Screen, Notify, and Treat group ($6745), and in Screen and Notify group ($6204). The difference was only significant in the Screen and Notify group versus the No Screen group (-$1236, 95% confidence interval -$2388 to -$96). Because mean QALYs were higher (+0.003 QALY in Screen and Notify; +0.004 QALYs in Screen, Notify, and Treat) and mean total costs were lower in both intervention groups, these interventions were cost-effective. There was substantial uncertainty because confidence intervals around cost differences were wide and QALY effects were small.

conclusionDepression screening strategies for patients with ACS may be modestly cost-effective.

Indexed as

Acute Coronary SyndromeCost-Benefit AnalysisDepressionHumansQuality-Adjusted Life YearsQuality of LifeAcute coronary syndromeCost-effectivenessDepressionQALYScreening

Identifiers

PMID33933921
PMCPMC10784112
OpenAlexW3143175661

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.