SynthesisNeuroscience and biobehavioral reviews2021
Distinct patterns of prefrontal cortical disengagement during inhibitory control in addiction: A meta-analysis based on population characteristics.
Synthesis in Neuroscience and biobehavioral reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 6 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 6 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Brain Structural Abnormalities in Addiction Disorders: Transdiagnostic Meta-Analyses.Human brain mapping · 2026Pooled it
- Neuroplasticity and recovery of the brain affected by substance use disorder: multilevel mechanisms and new therapeutic strategies (2020-2025).Frontiers in molecular neuroscience · 2026Pooled it
- Common and distinct patterns of brain activity alterations during inhibitory control in depression and psychostimulant users: a comparative meta-analysis of task-based fMRI studies.Psychological medicine · 2025Pooled it
- Neural mechanisms of behavioral addiction: An ALE meta-analysis and MACM analysis.Journal of behavioral addictions · 2025Pooled it
- Atypical local brain connectivity in pediatric autism spectrum disorder? A coordinate-based meta-analysis of regional homogeneity studies.European archives of psychiatry and clinical neuroscience · 2024Pooled it
- Neural underpinnings of response inhibition in substance use disorders: weak meta-analytic evidence for a widely used construct.Psychopharmacology · 2024Pooled it
- Article
- Neural Correlates of Inhibitory Control in Impulsivity Traits in Non-Ecological Human-Computer Tasks: An ALE Meta-Analysis.Brain sciences · 2026Review
- Neural imbalance between feedback sensitivity and motor inhibition in compulsivity and negative urgency.Translational psychiatry · 2026Article
- Transcranial direct current stimulation restores addictive behavior via prefrontal-striatal circuit.Molecular psychiatry · 2026Article
- The Effects of Pornographic Context on Working Memory Processing Among Individuals at Risk for Problematic Pornography Use.Archives of sexual behavior · 2026Article
- Resting-state EEG markers associated with violence risk in patients with major depressive disorder.Psychological medicine · 2026Article
- Machine Learning Classification of Smoking Behaviours-From Social Environment to the Prefrontal Cortex.Addiction biology · 2025Article
- From Smoking to Vaping: The Motivation for E-cigarette Use at the Neurobiological Level-A Functional Magnetic Resonance Imaging Study.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Article
- Structural Cerebellar and Lateral Frontoparietal Networks are altered in CUD: An SBM Analysis.Addiction biology · 2025Article
- Inhibitory control in the sober state as a function of alcohol sensitivity: a pilot functional magnetic resonance imaging (fMRI) study.Frontiers in human neuroscience · 2025Article
- Moderate tea consumption and dementia-related neuroimaging markers.Frontiers in neurology · 2025Article
- Neurobiological intersections of stress and substance use disorders.Frontiers in neuroscience · 2025Review
- Glutamate concentration of medial prefrontal cortex is inversely associated with addictive behaviors: a translational study.Translational psychiatry · 2024Article
- Assessment of rTMS treatment effects for methamphetamine addiction based on EEG functional connectivity.Cognitive neurodynamics · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Prefrontal cortical dysfunctions underlying inhibitory control deficits in addiction are complex and likely dependent on population characteristics. Here, we conducted a meta-analysis to examine alterations in brain activations during response inhibition in addicted individuals. We characterized imaging findings based on substance use status, diagnosis, substance classes, and task performance. Results revealed in those with active drug addiction hypoactivation of the left dorsal anterior cingulate cortex (dACC) and right middle frontal gyrus (MFG), compared with healthy controls. Weakening of the dACC and MFG activations was particularly pronounced in nicotine users, respectively. Impaired task performance was also associated with diminished MFG activation. In contrast, abstinent users did not exhibit any significant differences compared with healthy controls. Those with behavioral addictions were characterized by higher midcingulate cortical activation. Thus, the neural disengagement during response inhibition in active drug addiction was limited to a small number of prefrontal cortical regions and dependent on population characteristics. Finally, the evidence for potential normalization of hypofrontality following substance use cessation highlights the benefits of abstinence in restoring cerebral functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.