ArticleClinical nutrition (Edinburgh, Scotland)2022
Early caloric deficit is associated with a higher risk of death in invasive ventilated COVID-19 patients.
Article in Clinical nutrition (Edinburgh, Scotland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 30 citations in OpenAlex.
- Nutritional Risk Score (NRS-2002) as a Predictor of In-Hospital Mortality in COVID-19 Patients: A Retrospective Single-Center Cohort Study.Nutrients · 2025Article
- Can invasive interventions be avoided with a holistic swallowing therapy program in older patients in intensive care units: percutaneous endoscopic gastrostomy tubes or oral intake?Frontiers in neurology · 2025Article
- The Influence of Prone Positioning on Energy and Protein Delivery in COVID-19 Patients Requiring ECMO Support.Nutrients · 2024Article
- Inadequate Energy Delivery Is Frequent among COVID-19 Patients Requiring ECMO Support and Associated with Increased ICU Mortality.Nutrients · 2023Article
- Impact of nutritional therapy during the first wave of the COVID-19 pandemic in intensive care patients: A retrospective observational study.Clinical nutrition (Edinburgh, Scotland) · 2022Observational
- Nutritional management of individuals with obesity and COVID-19: ESPEN expert statements and practical guidance.Clinical nutrition (Edinburgh, Scotland) · 2022Article
- Nutritional parameters associated with prognosis in non-critically ill hospitalized COVID-19 patients: The NUTRI-COVID19 study.Clinical nutrition (Edinburgh, Scotland) · 2022Article
- Nutritional management and clinical outcome of critically ill patients with COVID-19: A retrospective study in a tertiary hospital.Clinical nutrition (Edinburgh, Scotland) · 2022Article
- COVID-19: Lessons on malnutrition, nutritional care and public health from the ESPEN-WHO Europe call for papers.Clinical nutrition (Edinburgh, Scotland) · 2022Article
- Nutrition support practices across the care continuum in a single centre critical care unit during the first surge of the COVID-19 pandemic - A comparison of VV-ECMO and non-ECMO patients.Clinical nutrition (Edinburgh, Scotland) · 2022Observational
- Gastrointestinal and sensory manifestations, nutrition management, and energy-protein intake in hospitalized patients with COVID-19.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2022Article
- Nutritional therapy for hospitalized patients with COVID-19: A narrative and integrative review.Journal of intensive medicine · 2022Review
- Specific nutrition and metabolic characteristics of critically ill patients with persistent COVID-19.JPEN. Journal of parenteral and enteral nutrition · 2022Observational
- Recovery Focused Nutritional Therapy across the Continuum of Care: Learning from COVID-19.Nutrients · 2021Review
- Nutrition guidelines for critically ill adults admitted with COVID-19: Is there consensus?Clinical nutrition ESPEN · 2021Review
- The Role of Dysbiosis in Critically Ill Patients With COVID-19 and Acute Respiratory Distress Syndrome.Frontiers in medicine · 2021Review
- Qualitative and quantitative muscle ultrasound changes in patients with COVID-19-related ARDS.Nutrition (Burbank, Los Angeles County, Calif.)Observational
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
aimsThe aim of this study was to evaluate the nutritional support management in mechanically ventilated coronavirus disease 2019 (COVID-19) patients and explore the association between early caloric deficit and mortality, taking possible confounders (i.e. obesity) into consideration.
methodsThis was a prospective study carried out during the first pandemic wave in the intensive care units (ICUs) of two referral University Hospitals in Lombardy, Italy. Two hundred twenty-two consecutive mechanically ventilated COVID-19 patients were evaluated during the ICU stay. In addition to major demographic and clinical data, we recorded information on the route and amount of nutritional support provided on a daily basis.
resultsAmong patients still in the ICUs and alive on day 4 (N = 198), 129 (65.2%) and 72 (36.4%) reached a satisfactory caloric and protein intake, respectively, mainly by enteral route. In multivariable analysis, a satisfactory caloric intake on day 4 was associated with lower mortality (HR = 0.46 [95%CI, 0.42-0.50], P < 0.001). Mild obesity (body mass index [BMI] ≥30 and < 35 kg/m
conclusionsThis study confirmed the negative prognostic and clinical role of obesity in mechanically ventilated COVID-19 patients and suggested that early caloric deficit may independently contribute to worsen survival in this patients' population. Therefore, any effort should be made to implement an adequate timely nutritional support in all COVID-19 patients during the ICU stay.
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