Evidence map›Paper›PMID 33933194›Full record

ArticleLancet (London, England)2021

Tocilizumab in COVID-19: some clarity amid controversy.

Shruti Gupta, David E Leaf

Abstract readComment
In one paragraph

Article in Lancet (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. IL-6 Inhibits Invasion in a Murine Model of Endometriosis.Reproductive sciences (Thousand Oaks, Calif.) · 2025
    Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. COVID-19 Therapeutics and Considerations for Pregnancy.Obstetrics and gynecology clinics of North America · 2023
    Review
  7. Observational
  8. Article
  9. Review
  10. Review
  11. Allocated but not treated: the silent 16.Lancet (London, England) · 2022
    Article
  12. Article
  13. Article
  14. Anakinra in COVID-19: A step closer to the cure.European journal of internal medicine · 2022
    Article
  15. Review
  16. Review
  17. Article
  18. Darunavir ethanolate: Repurposing an anti-HIV drug in COVID-19 treatment.European journal of medicinal chemistry reports · 2021
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Shruti GuptaDivision of Renal Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA, USA. Electronic address: sgupta21@bwh.harvard.edu.
David E LeafDivision of Renal Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA, USA.

Funding

Deferoxamine for the Prevention of Acute Kidney InjuryR01DK125786 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI LEAF, DAVID EVAN · 2020 to 2024
$3.5M
Precision Medicine Approach to Vitamin D3 Administration in Critical IllnessR01HL144566 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LEAF, DAVID EVAN · 2019 to 2022
$1.8M
NHLBI NIH HHS R01 HL144566NIDDK NIH HHS R01 DK125786
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

COVID-19 Drug TreatmentAntibodies, Monoclonal, HumanizedHospitalsHumansSARS-CoV-2Antibodies, Monoclonal, Humanizedtocilizumab

Identifiers

PMID33933194
PMCPMC8084409

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.