ArticleClinical immunology (Orlando, Fla.)2021
Anaphylaxis associated with the mRNA COVID-19 vaccines: Approach to allergy investigation.
Article in Clinical immunology (Orlando, Fla.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Poly(sarcosine) Lipid Synthesis From COMacromolecular rapid communications · 2026Article
- Developing mRNA Nanomedicines with Advanced Targeting Functions.Nano-micro letters · 2025Review
- Histopathological Patterns of Cutaneous Adverse Reaction to Anti-SARS-CoV-2 Vaccines: The Integrative Role of Skin Biopsy.Vaccines · 2023Review
- Recent developments in the immunopathology of COVID-19.Allergy · 2023Review
- Allergic adverse events following immunization: Data from post-marketing surveillance in Apulia region (South of Italy).Frontiers in immunology · 2023Observational
- Late Hypersensitivity Reactions to the BNT162b2 SARS-CoV-2 Vaccine Are Linked to Delayed Skin Sensitization and Prior Exposure to Hyaluronic Acid.Life (Basel, Switzerland) · 2022Article
- Pfizer-BioNTech (BNT162b2), Moderna (mRNA-1273) COVID-19 mRNA vaccines and hypersensitivity reactions.Journal of the National Medical Association · 2022Review
- SARS-CoV-2 Specific Humoral Immune Responses after BNT162b2 Vaccination in Hospital Healthcare Workers.Vaccines · 2022Article
- vACcine COnfidence amongst those living with alleRgy during the COVID pandemic (ACCORD): a scoping review protocol.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2022Article
- Optimization of Lipid Nanoparticles for saRNA Expression and Cellular Activation Using a Design-of-Experiment Approach.Molecular pharmaceutics · 2022Article
- [ARN COVID-19 COMIRNATY Vaccine desensitization in a case of PEG Severe Immediate Hypersensitivity].Revue francaise d'allergologie (2009) · 2022Article
- Cutaneous and hypersensitivity reactions associated with COVID-19 vaccination-a narrative review.Wiener medizinische Wochenschrift (1946) · 2022Review
- Cutaneous findings following COVID-19 vaccination: review of world literature and own experience.Journal of the European Academy of Dermatology and Venereology : JEADV · 2022Review
- The risk of anaphylaxis behind authorized COVID-19 vaccines: a meta-analysis.Clinical and molecular allergy : CMA · 2022Article
- Acquired hemophilia A after vaccination against SARS-CoV-2 with the mRNA-1273 (Moderna) vaccine.Proceedings (Baylor University. Medical Center) · 2022Article
- Safety & effectiveness of COVID-19 vaccines: A narrative review.The Indian journal of medical research · 2022Review
- Review
- The role of media messaging in COVID-19 vaccine hesitancy amongst the student population: Friend or foe.Pediatric pulmonology · 2021Article
- The clinical correlates of vaccine-induced immune thrombotic thrombocytopenia after immunisation with adenovirus vector-based SARS-CoV-2 vaccines.Immunotherapy advances · 2021Review
- Attention all anti-vaccinators: The cutaneous adverse events from the mRNA COVID-19 vaccines are not an excuse to avoid them!Clinics in dermatologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reports about cases of anaphylaxis to mRNA vaccines have created anxiety in the community and could increase vaccine hesitancy in the population. There are no standardized protocols for allergy testing to mRNA vaccines. PEG is currently the only excipient in both vaccines with recognized allergenic potential. Allergy to PEG has been reported with increasing frequency over recent years, often in patients who had repeated systemic allergic reactions/anaphylaxis to several classes of drugs before diagnosis. Proposed protocols are based on current knowledge about potential mechanisms of anaphylaxis associated with the mRNA vaccines, and the assumption that polyethylene glycol (PEG) is the most likely culprit. Allergy testing to PEGs and mRNA vaccines is complex and carries the risk of anaphylaxis and should be conducted in a specialist drug allergy center. Appropriate PEG-free emergency medical treatment and supervision should be readily available.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.