Evidence map›Paper›PMID 33932586›Full record

ArticleMolecular metabolism2021

Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion.

N Vishnu, A Hamilton, A Bagge, A Wernersson, E Cowan, H Barnard, Y Sancak, K J Kamer, P Spégel, M Fex and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Calcium signaling in mitochondrial intermembrane space.Biochemical Society transactions · 2024
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. CaCells · 2022
    Review
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

N VishnuUnit of Molecular Metabolism, Lund University Diabetes Center, Lund University, Malmö SE-205 02, Sweden.
A HamiltonUnit of Molecular Metabolism, Lund University Diabetes Center, Lund University, Malmö SE-205 02, Sweden.
A BaggeUnit of Molecular Metabolism, Lund University Diabetes Center, Lund University, Malmö SE-205 02, Sweden.
A WernerssonUnit of Molecular Metabolism, Lund University Diabetes Center, Lund University, Malmö SE-205 02, Sweden.
E CowanUnit of Molecular Metabolism, Lund University Diabetes Center, Lund University, Malmö SE-205 02, Sweden.
H BarnardUnit of Molecular Metabolism, Lund University Diabetes Center, Lund University, Malmö SE-205 02, Sweden.
Y SancakBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
K J KamerBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
P SpégelUnit of Molecular Metabolism, Lund University Diabetes Center, Lund University, Malmö SE-205 02, Sweden.
M FexUnit of Molecular Metabolism, Lund University Diabetes Center, Lund University, Malmö SE-205 02, Sweden.
A TengholmDepartment of Medical Cell Biology, Uppsala University, Uppsala SE-751 23, Sweden.
V K MoothaBroad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
D G NichollsUnit of Molecular Metabolism, Lund University Diabetes Center, Lund University, Malmö SE-205 02, Sweden; Buck Institute for Research on Aging, Novato, CA 94945, USA.
H MulderUnit of Molecular Metabolism, Lund University Diabetes Center, Lund University, Malmö SE-205 02, Sweden. Electronic address: Hindrik.mulder@med.lu.se.
Lund University · SEBroad Institute · USUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTransport of Ca

methodssiRNA silencing of Micu2 in the INS-1 832/13 and EndoC-βH1 cell lines was performed; Micu2

resultsSilencing of Micu2 abrogated GSIS in the INS-1 832/13 and EndoC-βH1 cells. The Micu2

conclusionsMICU2 plays a critical role in β cell mitochondrial Ca

Indexed as

CalciumCalcium-Binding ProteinsCalcium ChannelsInsulin-Secreting CellsInsulin SecretionAnimalsFemaleGene Knockdown TechniquesHEK293 CellsHumansMaleMiceMice, KnockoutMitochondriaMitochondrial MembranesRatsCalciumCalcium-Binding ProteinsCalcium ChannelsMICU2 protein, humanMicu2 protein, mousemicu2 protein, ratBioenergeticsKnockout miceMitochondrial calcium uniporterStimulus-secretion couplingVoltage-dependent calcium channels

Identifiers

PMID33932586
PMCPMC8163986
OpenAlexW3158183889

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.