Evidence map›Paper›PMID 33932551›Full record

ArticleNeuroscience research2021

Causal impact of local inflammation in the nasal cavity on higher brain function and cognition.

Yuto Hasegawa, Ho Namkung, Amy Smith, Shinji Sakamoto, Xiaolei Zhu, Koko Ishizuka, Andrew P Lane, Akira Sawa, Atsushi Kamiya

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Tuft Cells in the Gut Limit Cognitive Disorders by Regulating Gut Homeostasis.Cellular and molecular gastroenterology and hepatology · 2026
    Article
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  11. Air Pollution-Related Neurotoxicity Across the Life Span.Annual review of pharmacology and toxicology · 2023
    Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yuto HasegawaDepartment of Psychiatry, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.
Ho NamkungDepartment of Psychiatry, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD, 21287, USA; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.
Amy SmithDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.
Shinji SakamotoDepartment of Psychiatry, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.
Xiaolei ZhuDepartment of Psychiatry, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.
Koko IshizukaDepartment of Psychiatry, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.
Andrew P LaneDepartment of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD, 21287, USA.
Akira SawaDepartment of Psychiatry, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD, 21287, USA; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD, 21287, USA; Department of Neuroscience, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD, 21287, USA; Department of Genetic Medicine, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD, 21287, USA; Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health, 600 N. Wolfe Street, Baltimore, MD, 21287, USA. Electronic address: asawa1@jhmi.edu.
Atsushi KamiyaDepartment of Psychiatry, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, MD, 21287, USA. Electronic address: akamiya1@jhmi.edu.
Johns Hopkins University · US

Funding

Project 3P50MH094268 · NIMH · JOHNS HOPKINS UNIVERSITY · PI AVRAMOPOULOS, DIMITRIOS · 2011 to 2020
$19.9M
High throughput marker for cognitive deficit: cellular autofluorescenceR01MH107730 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2018 to 2022
$3.0M
Innate Immune Regulation of the Epithelium in Chronic Rhinosinusitis with Nasal PolypsR01AI132590 · NIAID · JOHNS HOPKINS UNIVERSITY · PI LANE, ANDREW P · 2018 to 2022
$3.0M
Molecular mechanism of astrocytic vulnerability to adolescent cannabis useR01DA041208 · NIDA · JOHNS HOPKINS UNIVERSITY · PI KAMIYA, ATSUSHI, PLETNIKOV, MIKHAIL V · 2016 to 2020
$2.9M
DISC1-dependent defects in neural fate, corticogenesis and cognition in psychosisR01MH105660 · NIMH · JOHNS HOPKINS UNIVERSITY · PI ISHIZUKA, KOKO, SAWA, AKIRA · 2014 to 2018
$2.8M
Inflammation-Associated Olfactory Dysfunction: Mechanisms and TherapyR01DC016106 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI LANE, ANDREW P · 2018 to 2022
$2.7M
Targeting age and gender-dependent microglia-mediated mechanisms underlying postoperative cognitive impairment for treatment of delirium in the elderlyR01AG065168 · NIA · JOHNS HOPKINS UNIVERSITY · PI KAMIYA, ATSUSHI · 2020 to 2024
$2.1M
Exploring a natural product to modulate aberrant gut bacterial-fungal interactions as pathological mechanisms underlying HIV-associated depressionK01AT010984 · NCCIH · JOHNS HOPKINS UNIVERSITY · PI ZHU, XIAOLEI · 2020 to 2024
$676k
NCCIH NIH HHS K01 AT010984NIAID NIH HHS R01 AI132590NIA NIH HHS R01 AG065168NIDA NIH HHS R01 DA041208NIDCD NIH HHS R01 DC016106NIMH NIH HHS P50 MH094268NIMH NIH HHS R01 MH105660NIMH NIH HHS R01 MH107730
6 · The paper itself

Abstract

Epidemiological evidence suggests that adverse environmental factors in the nasal cavity may increase the risk for neuropsychiatric diseases. For instance, air pollution and nasal viral infection have been underscored as risk factors for Parkinson's disease, schizophrenia, and mood disorders. These adverse factors can elicit local inflammation in the nasal cavity, which may in turn influence higher brain function. Nevertheless, evidence that directly supports their causal link is missing. To fill this knowledge gap, we used an inducible mouse model for olfactory inflammation and showed the evidence that this local pathological factor can elicit behavioral abnormalities.

Indexed as

COVID-19Nasal CavityAnimalsBrainCognitionInflammationMiceSARS-CoV-2AdolescenceCOVID-19Inducible olfactory inflammationNasal inflammationOlfactory epitheliumSARS-CoV-2Schizophrenia

Identifiers

PMID33932551
PMCPMC10693917
OpenAlexW3157383955

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.