Evidence map›Paper›PMID 33932436›Full record

ArticleBiophysical journal2021

Potassium channel blocker crafted by α-hairpinin scaffold engineering.

Valentin M Tabakmakher, Andrei M Gigolaev, Steve Peigneur, Nikolay A Krylov, Jan Tytgat, Anton O Chugunov, Alexander A Vassilevski, Roman G Efremov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biophysical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Valentin M TabakmakherShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia; School of Biomedicine, Far Eastern Federal University, Vladivostok, Russia.
Andrei M GigolaevShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
Steve PeigneurToxicology and Pharmacology, University of Leuven, Leuven, Belgium.
Nikolay A KrylovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia; National Research University Higher School of Economics, Moscow, Russia.
Jan TytgatToxicology and Pharmacology, University of Leuven, Leuven, Belgium.
Anton O ChugunovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia; National Research University Higher School of Economics, Moscow, Russia; Moscow Institute of Physics and Technology, Moscow State University, Dolgoprudny, Moscow Oblast, Russia.
Alexander A VassilevskiShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia; Moscow Institute of Physics and Technology, Moscow State University, Dolgoprudny, Moscow Oblast, Russia. Electronic address: avas@ibch.ru.
Roman G EfremovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia; National Research University Higher School of Economics, Moscow, Russia; Moscow Institute of Physics and Technology, Moscow State University, Dolgoprudny, Moscow Oblast, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The α-Hairpinins are a family of plant defense peptides with a common fold presenting two short α-helices stabilized by two invariant S-S-bridges. We have shown previously that substitution of just two amino acid residues in a wheat α-hairpinin Tk-AMP-X2 leads to Tk-hefu-2 that features specific affinity to voltage-gated potassium channels K

Indexed as

Potassium Channel BlockersScorpion VenomsAmino Acid SequenceMolecular Dynamics SimulationPeptidesProteinsPeptidesPotassium Channel BlockersProteinsScorpion Venoms

Identifiers

PMID33932436
PMCPMC8390879

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.