Evidence map›Paper›PMID 33932403›Full record

ArticleThe Journal of biological chemistry

Identification of multiple substrate binding sites in SLC4 transporters in the outward-facing conformation: Insights into the transport mechanism.

Hristina R Zhekova, Alexander Pushkin, Gülru Kayık, Liyo Kao, Rustam Azimov, Natalia Abuladze, Debra Kurtz, Mirna Damergi, Sergei Yu Noskov, Ira Kurtz

Open access · goldAbstract read
In one paragraph

Article in The Journal of biological chemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Novel functions of the anion exchanger AE4 (SLC4A9).Pflugers Archiv : European journal of physiology · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Bicarbonate-Independent Sodium Conductance of Na/HCOCurrent issues in molecular biology · 2022
    Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Hristina R ZhekovaCentre for Molecular Simulation, Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada.
Alexander PushkinDepartment of Medicine, Division of Nephrology, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Gülru KayıkCentre for Molecular Simulation, Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada.
Liyo KaoDepartment of Medicine, Division of Nephrology, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Rustam AzimovDepartment of Medicine, Division of Nephrology, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Natalia AbuladzeDepartment of Medicine, Division of Nephrology, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Debra KurtzDepartment of Medicine, Division of Nephrology, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Mirna DamergiCentre for Molecular Simulation, Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada.
Sergei Yu NoskovCentre for Molecular Simulation, Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada. Electronic address: snoskov@ucalgary.ca.
Ira KurtzDepartment of Medicine, Division of Nephrology, David Geffen School of Medicine, University of California, Los Angeles, California, USA; Brain Research Institute, University of California, Los Angeles, California, USA. Electronic address: ikurtz@mednet.ucla.edu.
University of California, Los Angeles · USUniversity of Calgary · CA

Funding

The Biology of NBCe1 in Health and DiseaseR01DK077162 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRA KURTZ · 2007 to 2026
$6.7M
Breakthrough Molecular Dynamics Research via an Anton2 SupercomputerR01GM116961 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI BLOOD, PHILIP D. · 2016 to 2023
$3.0M
NIDDK NIH HHS R01 DK077162NIGMS NIH HHS R01 GM116961
6 · The paper itself

Abstract

Solute carrier family 4 (SLC4) transporters mediate the transmembrane transport of HCO

Indexed as

Binding SitesBiological TransportHumansMolecular Dynamics SimulationProtein BindingProtein ConformationSolute Carrier ProteinsSolute Carrier ProteinsBand 3computer modelingelectrophysiologymembrane transportmolecular dynamicsNBCe1SILCSSLC4 proteinssubstrate binding sitestransporter

Identifiers

PMID33932403
PMCPMC8191340
OpenAlexW3159527433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.