Evidence map›Paper›PMID 33932263›Full record

ArticleEuropean journal of heart failure2021

The association between heart failure and incident cancer in women: an analysis of the Women's Health Initiative.

Douglas J Leedy, Kerryn W Reding, Alexi L Vasbinder, Garnet L Anderson, Ana Barac, Jean Wactawski-Wende, Aladdin H Shadyab, Charles B Eaton, Wayne C Levy, LiHong Qi and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Douglas J LeedyDepartment of Medicine, University of Washington School of Medicine, Seattle, WA, USA.
Kerryn W RedingDepartment of Biobehavioral Nursing and Health Informatics, University of Washington School of Nursing, Seattle, WA, USA.
Alexi L VasbinderDepartment of Biobehavioral Nursing and Health Informatics, University of Washington School of Nursing, Seattle, WA, USA.
Garnet L AndersonFred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA.
Ana BaracMedStar Heart and Vascular Institute, Medstar Washington Hospital Center, Georgetown University, Washington, DC, USA.
Jean Wactawski-WendeDepartment of Epidemiology and Environmental Health, University of Buffalo, Buffalo, NY, USA.
Aladdin H ShadyabDepartment of Family Medicine and Public Health, University of California San Diego School of Medicine, San Diego, CA, USA.
Charles B EatonDepartment of Family Medicine and Epidemiology, Alpert Medical School of Brown University, Providence, RI, USA.
Wayne C LevyDepartment of Medicine, University of Washington School of Medicine, Seattle, WA, USA.
LiHong QiDepartment of Public Health Sciences, University of California Davis School of Medicine, Sacramento, CA, USA.
Richard K ChengDepartment of Medicine, University of Washington School of Medicine, Seattle, WA, USA.
University of Washington · USBrown University · USFred Hutch Cancer Center · USGeorgetown University · USKaleida Health · USUniversity of California, Davis · USUniversity of San Diego · US

Funding

Biomarkers of Long-Term Fatigue in Breast Cancer Survivors Treated with RadiationF31NR018588 · NINR · UNIVERSITY OF WASHINGTON · PI VASBINDER, ALEXI L · 2019 to 2020
$89k
NHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNINR NIH HHS F31 NR018588
6 · The paper itself

Abstract

aimsThere is conflicting evidence whether heart failure (HF) is a risk factor for incident cancer. Despite population-based cohorts demonstrating this association, an analysis of the Physician's Health Study found no association in a cohort of mostly healthy males. We investigated the association of HF with incident cancer among a large cohort of post-menopausal women. METHODS AND

resultsA prospective cohort study of 146 817 post-menopausal women age 50 to 79 years enrolled in the Women's Health Initiative from 1993-1998, and followed through 2015. The primary exposure was adjudicated incident HF diagnosis, including preserved and reduced ejection fraction in a sub-cohort. The primary outcome was adjudicated incident total and site-specific cancers. Hazard ratios were calculated using multivariable-adjusted Cox proportional hazard regression models. Over a median follow-up of 8.4 years, 3272 and 17 474 women developed HF and cancer, respectively. HF developed in 235 women prior to cancer. HF was associated with subsequent incident cancer [hazard ratio (HR) 1.28, 95% confidence interval (CI) 1.11-1.48]. Associations were observed for obesity-related cancers (HR 1.24, 95% CI 1.02-1.51), as well as lung and colorectal cancers (HR 1.58, 95% CI 1.09-2.30 and HR 1.52, 95% CI 1.02-2.27, respectively). HF with preserved ejection fraction (HR 1.34, 95% CI 1.06-1.67), but not HF reduced ejection fraction (HR 0.99, 95% CI 0.74-1.34), was associated with total cancer.

conclusionHeart failure was associated with an increase in cancer diagnoses in post-menopausal women. This association was strongest for lung cancer. Further research is needed to appreciate the underlying mechanisms responsible for this association.

Indexed as

Heart FailureNeoplasmsAgedFemaleHumansIncidenceMaleMiddle AgedPostmenopauseProspective StudiesRisk FactorsWomen's HealthCancerCardio-oncologyHeart failureProspective cohortRisk

Identifiers

PMID33932263
PMCPMC8591611
OpenAlexW3158676465

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.