Evidence map›Paper›PMID 33932162›Full record

Trial reportPsychopharmacology2022

Sensory gating in tobacco-naïve cannabis users is unaffected by acute nicotine administration.

Ashley M Francis, Andrea Parks, Joëlle Choueiry, Nicole El-Marj, Danielle Impey, Verner J Knott, Derek J Fisher

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Psychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ashley M FrancisDepartment of Psychology, Saint Mary's University, Halifax, NS, Canada.
Andrea ParksDepartment of Biomedical Science, University of Ottawa, Ottawa, ON, Canada.
Joëlle ChoueiryDepartment of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.
Nicole El-MarjSchool of Psychology, University of Ottawa, Ottawa, ON, Canada.
Danielle ImpeyUniversity of Ottawa Institute of Mental Health Research, Ottawa, ON, Canada.
Verner J KnottDepartment of Biomedical Science, University of Ottawa, Ottawa, ON, Canada.
Derek J FisherDepartment of Psychology, Saint Mary's University, Halifax, NS, Canada. derek.fisher@msvu.ca.ORCID http://orcid.org/0000-0003-2366-8225
University of Ottawa · CASaint Mary's University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesLong-term cannabis use has been associated with the appearance of psychotic symptoms and schizophrenia-like cognitive impairments; however these studies may be confounded by concomitant use of tobacco by cannabis users. We aimed to determine if previously observed cannabis-associated deficits in sensory gating would be seen in cannabis users with no history of tobacco use, as evidenced by changes in the P50, N100, and P200 event-related potentials. A secondary objective of this study was to examine the effects of acute nicotine administration on cannabis users with no tobacco use history.

methodsThree components (P50, N100, P200) of the mid-latency auditory-evoked response (MLAER) were elicited by a paired-stimulus paradigm in 43 healthy, non-tobacco smoking male volunteers between the ages of 18-30. Cannabis users (CU, n = 20) were administered nicotine (6 mg) and placebo gum within a randomized, double-blind design. Non-cannabis users (NU, n = 23) did not receive nicotine.

resultsBetween-group sensory gating effects were only observed for the N100, with CUs exhibiting a smaller N100 to S

conclusionsThese findings suggest a relationship between gating impairment and cannabis use; however, acute nicotine administration nicotine does not appear to impact sensory gating function.

Indexed as

CannabisHallucinogensAcoustic StimulationAdolescentAdultCannabinoid Receptor AgonistsElectroencephalographyEvoked Potentials, AuditoryHumansMaleNicotianaNicotineSensory GatingYoung AdultCannabinoid Receptor AgonistsHallucinogensNicotineEvent-related potentialMarijuanaMid-latency auditory-evoked potentialMLAEPNicotineP50

Identifiers

PMID33932162
OpenAlexW3159774797

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.