Evidence map›Paper›PMID 33932116›Full record

ArticleESC heart failure2021

Parathormone levels add prognostic ability to N-terminal pro-brain natriuretic peptide in stable coronary patients.

Carlos Gutiérrez-Landaluce, Álvaro Aceña, Ana Pello, Juan Martínez-Milla, Óscar González-Lorenzo, Nieves Tarín, Carmen Cristóbal, Luis M Blanco-Colio, José Luis Martín-Ventura, Ana Huelmos and 10 more

Open access · goldAbstract read
In one paragraph

Article in ESC heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 9 institutions in 1 country.

Carlos Gutiérrez-LandaluceDepartment of Cardiology, Hospital Universitario de Fuenlabrada, Madrid, Spain.ORCID 0000-0001-5807-0894
Álvaro AceñaDepartment of Cardiology, IIS-Fundación Jiménez Díaz, Avda. Reyes Católicos 2, Madrid, 28040, Spain.
Ana PelloDepartment of Cardiology, IIS-Fundación Jiménez Díaz, Avda. Reyes Católicos 2, Madrid, 28040, Spain.
Juan Martínez-MillaDepartment of Cardiology, IIS-Fundación Jiménez Díaz, Avda. Reyes Católicos 2, Madrid, 28040, Spain.
Óscar González-LorenzoDepartment of Cardiology, IIS-Fundación Jiménez Díaz, Avda. Reyes Católicos 2, Madrid, 28040, Spain.
Nieves TarínDepartment of Cardiology, Hospital Universitario de Móstoles, Madrid, Spain.
Carmen CristóbalDepartment of Cardiology, Hospital Universitario de Fuenlabrada, Madrid, Spain.
Luis M Blanco-ColioLaboratory of Vascular Pathology, IIS-Fundación Jiménez Díaz, Madrid, Spain.
José Luis Martín-VenturaAutónoma University, Madrid, Spain.
Ana HuelmosDepartment of Cardiology, Hospital Universitario Fundación Alcorcón, Madrid, Spain.
Marta López-CastilloDepartment of Cardiology, IIS-Fundación Jiménez Díaz, Avda. Reyes Católicos 2, Madrid, 28040, Spain.
Joaquín AlonsoRey Juan Carlos University, Madrid, Spain.
Lorenzo López BescósRey Juan Carlos University, Madrid, Spain.
Luis Alonso-PulpónAutónoma University, Madrid, Spain.
Emilio González-ParraAutónoma University, Madrid, Spain.
Jesús EgidoAutónoma University, Madrid, Spain.
Ignacio Mahíllo-FernándezResearch Unit, IIS-Fundación Jiménez Díaz, Madrid, Spain.
Óscar LorenzoAutónoma University, Madrid, Spain.
María Luisa González-CasausLaboratory of Nephrology and Mineral Metabolism, Hospital Gómez-Ulla, Madrid, Spain.
José TuñónDepartment of Cardiology, IIS-Fundación Jiménez Díaz, Avda. Reyes Católicos 2, Madrid, 28040, Spain.
Hospital Universitario Fundación Jiménez Díaz · ESCentro de Investigación en Red en Enfermedades Cardiovasculares · ESUniversidad Rey Juan Carlos · ESCentro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas · ESHospital Central de la Defensa Gómez Ulla · ESHospital Universitario de Fuenlabrada · ESHospital Universitario de Móstoles · ESHospital Universitario Fundación Alcorcón · ESHospital Universitario Puerta de Hierro Majadahonda · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThere are controversial data on the ability of the components of mineral metabolism (vitamin D, phosphate, parathormone [PTH], fibroblast growth factor-23 [FGF23], and klotho) to predict cardiovascular events. In addition, it is unknown whether they add any prognostic value to other well-known biomarkers. METHODS AND

resultsIn 969 stable coronary patients, we determined plasma levels of all the aforementioned components of mineral metabolism with a complete set of clinical and biochemical variables, including N-terminal pro-brain natriuretic peptide (NT-proBNP), high-sensitivity troponin I (hs-TnI), and high-sensitivity C-reactive protein. Secondary outcomes were ischaemic events (any acute coronary syndrome, stroke, or transient ischaemic attack) and heart failure or death. The primary outcome was a composite of the secondary outcomes. Median follow-up was 5.39 years. Age was 60 (52-72) years. Median glomerular filtration rate was 80.4 (65.3-93.1) mL/min/1.73 m

conclusionsParathormone is an independent predictor of cardiovascular events in coronary patients, adding complimentary prognostic information to NT-proBNP plasma levels. This predictive value is restricted to patients with high FGF23 plasma levels. This should be considered in the design of future studies in this field.

Indexed as

Natriuretic Peptide, BrainPeptide FragmentsAgedFibroblast Growth Factor-23HumansMiddle AgedParathyroid HormonePrognosisFGF23 protein, humanFibroblast Growth Factor-23Natriuretic Peptide, BrainParathyroid HormonePeptide Fragmentspro-brain natriuretic peptide (1-76)Coronary artery diseaseFibroblast growth factor-23Mineral metabolismParathormone

Identifiers

PMID33932116
PMCPMC8318437
OpenAlexW3157526840

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.