Evidence map›Paper›PMID 33932109›Full record

ArticlePhysiological reports2021

Identification of novel bladder sensory GPCRs.

Tilmira A Smith, Brittni N Moore, Andres Matoso, Dan E Berkowitz, Jennifer J DeBerry, Jennifer L Pluznick

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Tilmira A SmithDepartment of Physiology, Johns Hopkins University, Baltimore, MD, USA.
Brittni N MooreDepartment of Physiology, Johns Hopkins University, Baltimore, MD, USA.
Andres MatosoDepartments of Pathology, Urology, and Oncology, Johns Hopkins University, Baltimore, MD, USA.
Dan E BerkowitzDepartment of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Jennifer J DeBerryDepartment of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Jennifer L PluznickDepartment of Physiology, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0003-3621-2665
Johns Hopkins University · USUniversity of Alabama at Birmingham · US

Funding

University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI W Timothy GARVEY · 2013 to 2026
$19.5M
QUANTITATIVE STUDY OF URINARY BLADDER SENSORY PROCESSINGR01DK051413 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DEBERRY, JENNIFER J, NESS, TIMOTHY J · 1997 to 2025
$5.4M
Microbial Short Chain Fatty Acids and Blood Pressure RegulationR01HL128512 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI PLUZNICK, JENNIFER L · 2016 to 2020
$2.0M
Uncovering the Functional Role of Olfr78 in Blood Pressure RegulationR01DK107726 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI PLUZNICK, JENNIFER L · 2016 to 2020
$1.8M
Optogenetic dissection of the functional properties of bladder afferent populationsK01DK101681 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DEBERRY, JENNIFER J · 2014 to 2018
$679k
NHLBI NIH HHS R01HL-128512NIDDK NIH HHS K01 DK101681NIDDK NIH HHS P30 DK079626NIDDK NIH HHS R01 DK051413NIDDK NIH HHS R01DK-107726
6 · The paper itself

Abstract

Sensory GPCRs such as olfactory receptors (ORs), taste receptors (TRs), and opsins (OPNs) are now known to play important physiological roles beyond their traditional sensory organs. Here, we systematically investigate the expression of sensory GPCRs in the urinary bladder for the first time. We find that the murine bladder expresses 16 ORs, 7 TRs, and 3 OPNs. We additionally explore the ectopic expression of these GPCRs in tissues beyond the bladder, as well as the localization within the bladder. In future work, understanding the functional roles of these bladder sensory GPCRs may shed light on novel mechanisms which modulate bladder function in health and disease.

Indexed as

AnimalsFemaleMaleMiceMice, Inbred C57BLOpsinsReceptors, OdorantUrinary BladderOpsinsReceptors, Odorantectopicolfactory receptoropsintaste receptor

Identifiers

PMID33932109
PMCPMC8087981
OpenAlexW3158130521

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.