Evidence map›Paper›PMID 33932059›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2021

Transmembrane Transport of Bicarbonate Unravelled*.

Luis Martínez-Crespo, Sarah H Hewitt, Nicola Alessandro De Simone, Vladimír Šindelář, Anthony P Davis, Stephen Butler, Hennie Valkenier

Open access · hybridAbstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 34 citations in OpenAlex.

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  12. Transmembrane Transport of Bicarbonate Unravelled*.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Luis Martínez-CrespoUniversité Libre de Bruxelles (ULB), Engineering of Molecular NanoSystems, Ecole polytechnique de Bruxelles, Avenue F.D. Roosevelt 50, CP165/64, 1050, Brussels, Belgium.ORCID http://orcid.org/0000-0001-5395-5562
Sarah H HewittLoughborough University, Department of Chemistry, Epinal Way, Loughborough, LE11 3TU, UK.ORCID http://orcid.org/0000-0002-7137-1314
Nicola Alessandro De SimoneMasaryk University, Department of Chemistry and RECETOX, Faculty of Science, Kamenice 5, 625 00, Brno, Czech Republic.ORCID http://orcid.org/0000-0002-9868-6957
Vladimír ŠindelářMasaryk University, Department of Chemistry and RECETOX, Faculty of Science, Kamenice 5, 625 00, Brno, Czech Republic.ORCID http://orcid.org/0000-0003-0090-5961
Anthony P DavisUniversity of Bristol, School of Chemistry, Cantock's Close, Bristol, BS8 1TS, UK.ORCID http://orcid.org/0000-0001-5213-624X
Stephen ButlerLoughborough University, Department of Chemistry, Epinal Way, Loughborough, LE11 3TU, UK.ORCID http://orcid.org/0000-0001-8109-3330
Hennie ValkenierUniversité Libre de Bruxelles (ULB), Engineering of Molecular NanoSystems, Ecole polytechnique de Bruxelles, Avenue F.D. Roosevelt 50, CP165/64, 1050, Brussels, Belgium.ORCID http://orcid.org/0000-0002-4409-0154
Loughborough University · GBMasaryk University · CZUniversité Libre de Bruxelles · BEUniversity of Bristol · GB

Funding

Czech Science Foundation 20-13922SEngineering and Physical Sciences Research Council EP/S032339/1EPSRC EP/S032339/1European Research Council 802727European Research Council (ERC)European Union's Horizon 2020 802727Fonds de la Recherche Scientifique - FNRSFonds De La Recherche Scientifique - FNRSGrantová Agentura České Republiky No. 20-13922SULBWellcome TrustWellcome Trust 204500/Z/16/Z
6 · The paper itself

Abstract

Anion receptors can be used to transport ions across lipid bilayers, which has potential for therapeutic applications. Synthetic bicarbonate transporters are of particular interest, as defects in transmembrane transport of bicarbonate are associated with various diseases. However, no convenient method exists to directly observe bicarbonate transport and study the mechanisms involved. Here, an assay is presented that allows the kinetics of bicarbonate transport into liposomes to be monitored directly and with great sensitivity. The assay utilises an encapsulated europium(III) complex, which exhibits a large increase in emission intensity upon binding bicarbonate. Mechanisms involving CO

Indexed as

BicarbonatesLipid BilayersBiological TransportHydrogen-Ion ConcentrationIon TransportKineticsBicarbonatesLipid Bilayersbicarbonatefluorescent probesion transportmembranessupramolecular chemistry

Identifiers

PMID33932059
PMCPMC8251953
OpenAlexW3157676873

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.