ArticleCancer medicine2021
Surgery shows survival benefit in patients with primary intestinal diffuse large B-cell lymphoma: A population-based study.
Article in Cancer medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- The surgery for the patients with intestinal non‑Hodgkin lymphomas: a nationwide study.Annals of medicine · 2026Article
- Heterogeneity in primary gastrointestinal DLBCL: from clinical management to molecular mechanisms and treatment strategies.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- ASO Author Reflections: Reconsidering the Role of Surgery in Intestinal Diffuse Large B-Cell Lymphoma (DLBCL).Annals of surgical oncology · 2026Article
- The Role of Surgery in the Management of Intestinal Diffuse Large B-Cell Lymphoma (DLBCL): A Propensity Score-Matched Analysis.Annals of surgical oncology · 2026Article
- Anatomical laterality of primary intestinal diffuse large B-cell lymphoma independently stratifies survival: New prognostic nomogram incorporating tumor location.World journal of gastroenterology · 2026Article
- Unmasking small-bowel DLBCL in an elderly patient with simultaneous multiple primary cancers through anemia: a case report and literature review.Frontiers in oncology · 2026Article
- Clinical Features and Outcomes of Primary Colorectal Diffuse Large B-Cell Lymphoma: A Multicenter Retrospective Study.Cancer medicine · 2025Article
- Thrombosis risk prediction in lymphoma patients: A multi-institutional, retrospective model development and validation study.American journal of hematology · 2024Article
- Primary intestinal diffuse large B-cell lymphoma: novel insights and clinical perception.Frontiers in oncology · 2024Article
- Profiling risk factors for separation of infection complications in patients with gastrointestinal and nodal diffuse large B-cell lymphoma.BMC infectious diseases · 2023Article
- Traumatic Rupture of Cystic Left Retroperitoneal Mass: An Atypical Presentation of Diffuse Large B-Cell Lymphoma.Cureus · 2023Article
- A Novel and Validated Inflammation-Based Prognosis Score (IBPS) Predicts Outcomes in Patients with Diffuse Large B-Cell Lymphoma.Cancer management and research · 2023Article
- 5-Hydroxymethylation alterations in cell-free DNA reflect molecular distinctions of diffuse large B cell lymphoma at different primary sites.Clinical epigenetics · 2022Article
- Article
- A Novel Prognostic Model for Patients with Primary Gastric Diffuse Large B-Cell Lymphoma.Journal of oncology · 2022Article
- Primary diffuse large B-cell lymphoma of orbit: A population-based analysis.Frontiers in medicine · 2022Article
- Clinical Features and Prognosis of Patients with Primary Intestinal B-cell Lymphoma Treated with Chemotherapy with or without Surgery.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2021Article
- The impact of surgery on long-term survival of patients with primary intestinal non-Hodgkin lymphomas based on SEER database.Scientific reports · 2021Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe clinical characteristics and prognosis of primary intestinal diffuse large B-cell lymphoma (PI-DLBCL) are rarely reported. We aimed to explore the role of surgery in patients with PI-DLBCL.
methodsAdult PI-DLBCL patients were included from the Surveillance, Epidemiology, and End Results database. The effect of surgery was evaluated by Kaplan-Meier and Cox proportional regression analyses. Propensity score matching (PSM) was used to reinforce our results. Lasso regression was utilized to determine independent risk factors of overall survival (OS) for a nomogram and a novel web-based calculator. The performance of the model was measured via concordance index, receiver operating characteristic curve, and calibration plots in both cohorts.
resultsOverall, 1602 patients with PI-DLBCL were analyzed. Surgery significantly improved survival in both univariate and multivariate analyses (p = 0.007, p < 0.001, respectively). Before PSM, local tumor destruction (LTD) displayed a survival advantage over resection in patients without chemotherapy (p = 0.034). After PSM, surgery was still identified as a beneficial factor for OS (p = 0.0015). However, there was no statistical difference between LTD and resection (p = 0.32). The nomogram for 3-, 5-, and 10-year OS predictions exhibited dependable consistency between internal and external validation.
conclusionThis study approves the beneficial effect of surgery on clinical endpoints in PI-DLBCL patients. For those who are not suitable for resection, LTD may also be a practical option. The predictive nomogram and the web-based calculator could help clinicians individually evaluate the prognosis and optimize personalized treatment decisions for these patients.
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