Evidence map›Paper›PMID 33931865›Full record

ArticleBritish journal of pharmacology2021

Involvement of 3',5'-cyclic inosine monophosphate in cystathionine γ-lyase-dependent regulation of the vascular tone.

Emma Mitidieri, Valentina Vellecco, Vincenzo Brancaleone, Domenico Vanacore, Onorina L Manzo, Emil Martin, Iraida Sharina, Yekaterina Krutsenko, Maria Chiara Monti, Elva Morretta and 7 more

Open access · greenAbstract read
In one paragraph

Article in British journal of pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. HHandbook of experimental pharmacology · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. The Protective Effects of Ganoderic Acids fromFoods (Basel, Switzerland) · 2022
    Article
  8. Article
  9. Article
  10. Hydrogen Sulfide (HBiomolecules · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 4 countries.

Emma MitidieriDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.ORCID 0000-0003-4372-9611
Valentina VelleccoDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.ORCID 0000-0002-5674-9112
Vincenzo BrancaleoneDepartment of Science, University of Basilicata, Potenza, Italy.ORCID 0000-0002-0063-659X
Domenico VanacoreDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Onorina L ManzoDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Emil MartinMcGovern Medical School, Department of Internal Medicine, Division of Cardiology, University of Texas Health Science Center, Houston, Texas, USA.
Iraida SharinaMcGovern Medical School, Department of Internal Medicine, Division of Cardiology, University of Texas Health Science Center, Houston, Texas, USA.
Yekaterina KrutsenkoSchool of Science and Technology, Nazarbayev University, Astana, Kazakhstan.
Maria Chiara MontiDepartment of Pharmacy, University of Salerno, Fisciano, SA, Italy.
Elva MorrettaDepartment of Pharmacy, University of Salerno, Fisciano, SA, Italy.ORCID 0000-0002-7244-0297
Andreas PapapetropoulosLaboratory of Pharmacology, Department of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.
Giuseppe CaliendoDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Francesco FrecenteseDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Giuseppe CirinoDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Raffaella SorrentinoDepartment of Molecular Medicine and Medical Biotechnology, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.ORCID 0000-0002-0284-5424
Roberta d'Emmanuele di Villa BiancaDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.ORCID 0000-0003-0992-6400
Mariarosaria BucciDepartment of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Naples, Italy.ORCID 0000-0001-5502-4315
University of Naples Federico II · ITThe University of Texas Health Science Center at Houston · USUniversity of Salerno · ITNational and Kapodistrian University of Athens · GRNazarbayev University · KZUniversity of Basilicata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposel-cysteine or hydrogen sulfide (H EXPERIMENTAL APPROACH: Vascular response to NaHS or l-cysteine is evaluated on isolated precontracted with phenylephrine vessel rings harvested from wild type, cystathionine γ-lyase (CSE KEY

resultsCSE-derived H CONCLUSION AND IMPLICATIONS: The endothelium dynamically regulates vessel homeostasis by modulating contractile tone. This also involves CSE-derived H

Indexed as

Cystathionine gamma-LyaseHydrogen SulfideAnimalsChromatography, LiquidCyclic GMPInosine MonophosphateMiceNitric OxideTandem Mass SpectrometryCyclic GMPCystathionine gamma-LyaseHydrogen SulfideInosine MonophosphateNitric Oxidecyclic nucleotidescystathionine γ-lyasegasotransmittersinosine 3′,5′-cyclic monophosphatephosphodiesterasesvascular homeostasisvasoconstriction

Identifiers

PMID33931865
PMCPMC8453910
OpenAlexW3157344432

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.