ArticleScientific reports2021
Interfacing aptamers, nanoparticles and graphene in a hierarchical structure for highly selective detection of biomolecules in OECT devices.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Glucose-Derived Carbon Materials via Hydrothermal Carbonization and Pyrolysis for Electrochemical Applications.ACS omega · 2026Article
- Miniaturization of Aptasensors in Organic Electrochemical Transistors for Sensitivity Enhancement.Analytical chemistry · 2026Article
- Flexible Multimodal Neural Probe with Integrated Three-Electrode Aptameric Sensing for In Vivo Monitoring of Dopamine Dynamics and Neural Activity.ACS chemical neuroscience · 2026Article
- Aerosol Jet Printing in Biotechnologies.Bioengineering (Basel, Switzerland) · 2026Review
- Nucleic acid-based wearable and implantable electrochemical sensors.Chemical Society reviews · 2024Review
- Organic Electronics-Microfluidics/Lab on a Chip Integration in Analytical Applications.Sensors (Basel, Switzerland) · 2023Review
- Detection of Listeria monocytogenes in foods with a textile organic electrochemical transistor biosensor.Applied microbiology and biotechnology · 2023Article
- Lab on a Chip Device for Diagnostic Evaluation and Management in Chronic Renal Disease: A Change Promoting Approach in the Patients' Follow Up.Biosensors · 2023Review
- Organic Bioelectronics Development in Italy: A Review.Micromachines · 2023Review
- Design of a Portable Microfluidic Platform for EGOT-Based in Liquid Biosensing.Sensors (Basel, Switzerland) · 2022Article
- Homocysteine Solution-Induced Response in Aerosol Jet Printed OECTs by Means of Gold and Platinum Gate Electrodes.International journal of molecular sciences · 2021Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In several biomedical applications, the detection of biomarkers demands high sensitivity, selectivity and easy-to-use devices. Organic electrochemical transistors (OECTs) represent a promising class of devices combining a minimal invasiveness and good signal transduction. However, OECTs lack of intrinsic selectivity that should be implemented by specific approaches to make them well suitable for biomedical applications. Here, we report on a biosensor in which selectivity and a high sensitivity are achieved by interfacing, in an OECT architecture, a novel gate electrode based on aptamers, Au nanoparticles and graphene hierarchically organized to optimize the final response. The fabricated biosensor performs state of the art limit of detection monitoring biomolecules, such as thrombin-with a limit of detection in the picomolar range (≤ 5 pM) and a very good selectivity even in presence of supraphysiological concentrations of Bovine Serum Albumin (BSA-1mM). These accomplishments are the final result of the gate hierarchic structure that reduces sterich indrance that could contrast the recognition events and minimizes false positive, because of the low affinity of graphene towards the physiological environment. Since our approach can be easily applied to a large variety of different biomarkers, we envisage a relevant potential for a large series of different biomedical applications.
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Registered trials
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