ArticleHorticulture research2021
CsbZIP1-CsMYB12 mediates the production of bitter-tasting flavonols in tea plants (Camellia sinensis) through a coordinated activator-repressor network.
Article in Horticulture research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 98 citations in OpenAlex.
- CsWRKY22 positively regulates quercetin biosynthesis by activating the CsFLSd promoter in tea plants (Camellia sinensis).Plant cell reports · 2026Article
- The RcMYB21 transcription factor activates flavonol biosynthesis by targeting RcFLS in Chinese raspberry.BMC plant biology · 2026Article
- Anthocyanin accumulation differences in European pears caused by Phytochrome-interacting factor 3 (PcPIF3) promoter mutations under UV-B.Journal of advanced research · 2026Article
- Unraveling the multifaceted roles of theForestry research · 2026Article
- Integrated single-nucleus transcriptomic and metabolomic insights into bud-to-leaf development and metabolite synthesis in tea plant.Horticulture research · 2026Article
- Multi-omics analysis reveals the regulatory mechanism of shading on quality-related metabolites inFood chemistry. Molecular sciences · 2025Article
- Genome-Wide Screening for MYB Transcription Factors Involved in Flavonoid Glycoside Biosynthesis inGenes · 2025Article
- Influencing Factors and Regulatory Mechanisms of Fresh Tea Leaf Quality: A Review.Foods (Basel, Switzerland) · 2025Review
- Functional analysis of a UDP-glucosyltransferase gene contributing to biosynthesis of the flavonol triglycoside in tea plants.Horticulture research · 2025Article
- A model for the adaptation of Euryale ferox leaves to aquatic environments through EfCGT1-controlled flavonoid C-glycoside-specific accumulation in epidermis cells.Plant biotechnology journal · 2025Article
- CsHY5 Regulates Light-Induced Anthocyanin Accumulation inInternational journal of molecular sciences · 2025Article
- Exploring seasonal differences in taste and nonvolatiles ofFood chemistry: X · 2025Article
- Revealing the Molecular Regulatory Mechanism of Flavonoid Accumulation in Tender Leaves of Tea Plants by Transcriptomic and Metabolomic Analyses.Plants (Basel, Switzerland) · 2025Article
- Tissue-specific transcriptome analyses unveils candidate genes for flavonoid biosynthesis, regulation and transport in the medicinal plant Ilex asprella.Scientific reports · 2024Article
- Gibberellin 2-oxidase 1(CsGA2ox1) involved gibberellin biosynthesis regulates sprouting time in camellia sinensis.BMC plant biology · 2024Article
- A functional study reveals CsNAC086 regulated the biosynthesis of flavonols in Camellia sinensis.Planta · 2024Article
- Transcriptional regulation of flavonol biosynthesis in plants.Horticulture research · 2024Review
- CsMYB73 negatively regulates theanine accumulation mediated byHorticulture research · 2024Article
- UV-B induced flavonoid accumulation and related gene expression in blue- grained wheat at different periods of time.Frontiers in plant science · 2024Article
- CsMYB67 participates in the flavonoid biosynthesis of summer tea leaves.Horticulture research · 2024Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
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Abstract
Under high light conditions or UV radiation, tea plant leaves produce more flavonols, which contribute to the bitter taste of tea; however, neither the flavonol biosynthesis pathways nor the regulation of their production are well understood. Intriguingly, tea leaf flavonols are enhanced by UV-B but reduced by shading treatment. CsFLS, CsUGT78A14, CsMYB12, and CsbZIP1 were upregulated by UV-B radiation and downregulated by shading. CsMYB12 and CsbZIP1 bound to the promoters of CsFLS and CsUGT78A14, respectively, and activated their expression individually. CsbZIP1 positively regulated CsMYB12 and interacted with CsMYB12, which specifically activated flavonol biosynthesis. Meanwhile, CsPIF3 and two MYB repressor genes, CsMYB4 and CsMYB7, displayed expression patterns opposite to that of CsMYB12. CsMYB4 and CsMYB7 bound to CsFLS and CsUGT78A14 and repressed their CsMYB12-activated expression. While CsbZIP1 and CsMYB12 regulated neither CsMYB4 nor CsMYB7, CsMYB12 interacted with CsbZIP1, CsMYB4, and CsMYB7, but CsbZIP1 did not physically interact with CsMYB4 or CsMYB7. Finally, CsPIF3 bound to and activated CsMYB7 under shading to repress flavonol biosynthesis. These combined results suggest that UV activation and shading repression of flavonol biosynthesis in tea leaves are coordinated through a complex network involving CsbZIP1 and CsPIF3 as positive MYB activators and negative MYB repressors, respectively. The study thus provides insight into the regulatory mechanism underlying the production of bitter-tasting flavonols in tea plants.
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