ArticleHorticulture research2021
The domestication of Cucurbita argyrosperma as revealed by the genome of its wild relative.
Article in Horticulture research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Telomere-to-telomere genome assembly of pumpkin (Horticulture research · 2026Article
- Telomere-to-telomere genome assembly and a mutant library empower functional genomics and genetic improvement in Cucurbita moschata.Plant communications · 2026Article
- Comparative analysis of the Aquaporin gene family in Cucurbitaceae: insights into evolutionary patterns and functional diversity.BMC plant biology · 2026Article
- Comparative complete chloroplast genome analysis ofFrontiers in plant science · 2026Article
- Chromosome-specific oligo-painting provides insights into the cytogenetic basis of karyotypic stasis in paleo-allotetraploidHorticulture research · 2025Article
- How social and economic policies have affected the genome of mezcal agaves: The contrasting stories of Bacanora and Espadín.PloS one · 2025Article
- Cultivar-Specific Defense Responses in Wild and Cultivated Squash Induced by Belowground and Aboveground Herbivory.Journal of chemical ecology · 2024Article
- Population Genomics of DomesticatedPlants (Basel, Switzerland) · 2023Article
- Article
- Consequences of squash (Cucurbita argyrosperma) domestication for plant defence and herbivore interactions.Planta · 2023Article
- CuGenDBv2: an updated database for cucurbit genomics.Nucleic acids research · 2023Article
- Impact of LTR-Retrotransposons on Genome Structure, Evolution, and Function in Curcurbitaceae Species.International journal of molecular sciences · 2022Article
- Prediction of NB-LRR resistance genes based on full-length sequence homology.The Plant journal : for cell and molecular biology · 2022Article
- The effect of squash domestication on a belowground tritrophic interaction.Plant-environment interactions (Hoboken, N.J.) · 2022Article
- Large-scale gene gains and losses molded the NLR defense arsenal during the Cucurbita evolution.Planta · 2021Article
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Authors and funding
10 authors.
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Abstract
Despite their economic importance and well-characterized domestication syndrome, the genomic impact of domestication and the identification of variants underlying the domestication traits in Cucurbita species (pumpkins and squashes) is currently lacking. Cucurbita argyrosperma, also known as cushaw pumpkin or silver-seed gourd, is a Mexican crop consumed primarily for its seeds rather than fruit flesh. This makes it a good model to study Cucurbita domestication, as seeds were an essential component of early Mesoamerican diet and likely the first targets of human-guided selection in pumpkins and squashes. We obtained population-level data using tunable Genotype by Sequencing libraries for 192 individuals of the wild and domesticated subspecies of C. argyrosperma across Mexico. We also assembled the first high-quality wild Cucurbita genome. Comparative genomic analyses revealed several structural variants and presence/absence of genes related to domestication. Our results indicate a monophyletic origin of this domesticated crop in the lowlands of Jalisco. We found evidence of gene flow between the domesticated and wild subspecies, which likely alleviated the effects of the domestication bottleneck. We uncovered candidate domestication genes that are involved in the regulation of growth hormones, plant defense mechanisms, seed development, and germination. The presence of shared selected alleles with the closely related species Cucurbita moschata suggests domestication-related introgression between both taxa.
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