Evidence map›Paper›PMID 33931465›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2022

First-in-Human PET Imaging and Estimated Radiation Dosimetry of l-[5-

Allison S Cohen, Joe Grudzinski, Gary T Smith, Todd E Peterson, Jennifer G Whisenant, Tiffany L Hickman, Kristen K Ciombor, Dana Cardin, Cathy Eng, Laura W Goff and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 30 citations in OpenAlex.

  1. Results of the Phase I/II Study and Preliminary B-cell Gene Signature of Combined Inhibition of Glutamine Metabolism and EGFR in Colorectal Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Trial
  2. Glutamine metabolism in health and disease.Signal transduction and targeted therapy · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. l-[5-Acta pharmaceutica Sinica. B · 2025
    Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Noninvasive Stratification of Colon Cancer by Multiplex PET Imaging.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Allison S CohenVanderbilt Center for Molecular Probes, Vanderbilt University Medical Center, Nashville, Tennessee.
Joe GrudzinskiInternal Dosimetry Consultants, LLC, Madison, Wisconsin.
Gary T SmithDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.
Todd E PetersonVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee.
Jennifer G WhisenantDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Tiffany L HickmanVanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee; and.
Kristen K CiomborDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Dana CardinDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Cathy EngDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Laura W GoffDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Satya DasDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Robert J CoffeyDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Jordan D BerlinDepartment of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
H Charles ManningVanderbilt Center for Molecular Probes, Vanderbilt University Medical Center, Nashville, Tennessee; hcmanning@mdanderson.org.
Vanderbilt University Medical Center · USThe University of Texas MD Anderson Cancer Center · USVanderbilt University · US

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8M
Vanderbilt-Ingram Cancer Center SPORE in Gastrointestinal CancerP50CA236733 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Robert J. Coffey · 2019 to 2026
$19.6M
Vanderbilt Clinical Oncology Research Career Development ProgramK12CA090625 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Debra L. Friedman, Paula Jill Hurley · 2001 to 2026
$16.9M
Project 3: Inhibiting Oxidative Phosphorylation in Pancreatic CancerP50CA221707 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KOPETZ, SCOTT, MAITRA, ANIRBAN · 2019 to 2023
$11.0M
Integrated approach to study early and late events in colonic neoplasia: mouse to manR35CA197570 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Robert J. Coffey · 2017 to 2026
$9.4M
VU PREDICTU24CA220325 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KOPETZ, SCOTT, MANNING, HENRY CHARLES · 2018 to 2022
$3.3M
A PET-CT Scanner for Translational ResearchS10OD012297 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GORE, JOHN C · 2015 to 2015
$2.0M
Radiofluorination Equipment for PET Imaging ResearchS10OD019963 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MANNING, HENRY CHARLES · 2016 to 2016
$291k
NCI NIH HHS K12 CA090625NCI NIH HHS P30 CA068485NCI NIH HHS P50 CA221707NCI NIH HHS P50 CA236733NCI NIH HHS R35 CA197570NCI NIH HHS U24 CA220325NIH HHS S10 OD012297NIH HHS S10 OD019963
6 · The paper itself

Abstract

Altered metabolism is a hallmark of cancer. In addition to glucose, glutamine is an important nutrient for cellular growth and proliferation. Noninvasive imaging via PET may help facilitate precision treatment of cancer through patient selection and monitoring of treatment response. l-[5-

Indexed as

Colorectal NeoplasmsGlutamineNeoplasm MetastasisRadiometryAgedCarbon RadioisotopesFemaleHumansMaleMiddle AgedPositron-Emission TomographyPositron Emission Tomography Computed TomographyRadiopharmaceuticalsTissue DistributionCarbon-11Carbon RadioisotopesGlutamineRadiopharmaceuticals11C-glutaminecolorectal cancermetabolismPET

Identifiers

PMID33931465
PMCPMC8717201
OpenAlexW3158631244

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.