Evidence map›Paper›PMID 33931449›Full record

ArticleScience advances2021

Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes.

Daniela Ivanova, Katharine L Dobson, Akshada Gajbhiye, Elizabeth C Davenport, Daniela Hacker, Sila K Ultanir, Matthias Trost, Michael A Cousin

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 37 citations in OpenAlex.

  1. Reversible synaptic deficits in early-stage batten disease.Journal of translational medicine · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Biogenesis and reformation of synaptic vesicles.The Journal of physiology · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Chloroquine impairs maximal transdiaphragmatic pressure generation in old mice.Journal of applied physiology (Bethesda, Md. : 1985) · 2023
    Article
  14. Article
  15. Article
  16. FMRP Sustains Presynaptic Function via Control of Activity-Dependent Bulk Endocytosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  17. Review
  18. The function of VAMP2 in mediating membrane fusion: An overview.Frontiers in molecular neuroscience · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Daniela IvanovaCentre for Discovery Brain Sciences, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh EH8 9XD, Scotland. d.Ivanova@ed.ac.uk daniela_as_ivanova@abv.bg m.cousin@ed.ac.uk.ORCID 0000-0002-5378-0210
Katharine L DobsonCentre for Discovery Brain Sciences, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh EH8 9XD, Scotland.ORCID 0000-0003-4117-8684
Akshada GajbhiyeNewcastle University Biosciences Institute, Faculty of Medical Sciences, Newcastle upon Tyne NE2 4HH, UK.ORCID 0000-0002-6525-7603
Elizabeth C DavenportCentre for Discovery Brain Sciences, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh EH8 9XD, Scotland.ORCID 0000-0002-4652-0234
Daniela HackerCentre for Discovery Brain Sciences, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh EH8 9XD, Scotland.ORCID 0000-0001-6922-7017
Sila K UltanirThe Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.ORCID 0000-0001-5745-3957
Matthias TrostNewcastle University Biosciences Institute, Faculty of Medical Sciences, Newcastle upon Tyne NE2 4HH, UK.ORCID 0000-0002-5732-700X
Michael A CousinCentre for Discovery Brain Sciences, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh EH8 9XD, Scotland. d.Ivanova@ed.ac.uk daniela_as_ivanova@abv.bg m.cousin@ed.ac.uk.ORCID 0000-0002-1762-160X
MRC Centre for Regenerative Medicine · GBNewcastle University · GBThe Francis Crick Institute · GB

Funding

Medical Research Council FC001201Wellcome Trust 204954/Z/16/Z
6 · The paper itself

Abstract

Synaptic vesicle (SV) release probability (Pr), determines the steady state and plastic control of neurotransmitter release. However, how diversity in SV composition arises and regulates the Pr of individual SVs is not understood. We found that modulation of the copy number of the noncanonical vesicular SNARE (soluble

Identifiers

PMID33931449
PMCPMC8087399
OpenAlexW3158835541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.