Evidence map›Paper›PMID 33931448›Full record

ArticleScience advances2021

A highly conserved 3

Aileen J Lam, Lu Rao, Yuzu Anazawa, Kyoko Okada, Kyoko Chiba, Mariah Dacy, Shinsuke Niwa, Arne Gennerich, Dan W Nowakowski, Richard J McKenney

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Deciphering European Sea Bass (International journal of molecular sciences · 2025
    Article
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  10. Article
  11. Article
  12. Article
  13. Article
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  15. Article
  16. Article
  17. Article
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  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Aileen J LamDepartment of Molecular and Cellular Biology, University of California, Davis. Davis, CA 95616, USA.ORCID 0000-0001-8309-6033
Lu RaoDepartment of Anatomy and Structural Biology and Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.ORCID 0000-0002-7447-1484
Yuzu AnazawaDepartment of Biology, Faculty of Science, Tohoku University, Sendai, 980-8578 Miyagi, Japan.
Kyoko OkadaDepartment of Molecular and Cellular Biology, University of California, Davis. Davis, CA 95616, USA.
Kyoko ChibaDepartment of Molecular and Cellular Biology, University of California, Davis. Davis, CA 95616, USA.
Mariah DacyDepartment of Molecular and Cellular Biology, University of California, Davis. Davis, CA 95616, USA.
Shinsuke NiwaFrontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, 980-0845 Miyagi, Japan.
Arne GennerichDepartment of Anatomy and Structural Biology and Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA. arne.gennerich@einsteinmed.org publications@nmolecularsystems.com rjmckenney@ucdavis.edu.ORCID 0000-0002-8346-5473
Dan W NowakowskiN Molecular Systems Inc., Palo Alto, CA 94303, USA. arne.gennerich@einsteinmed.org publications@nmolecularsystems.com rjmckenney@ucdavis.edu.ORCID 0000-0001-8660-7126
Richard J McKenneyDepartment of Molecular and Cellular Biology, University of California, Davis. Davis, CA 95616, USA. arne.gennerich@einsteinmed.org publications@nmolecularsystems.com rjmckenney@ucdavis.edu.ORCID 0000-0002-8423-0852
University of California, Davis · USTohoku University · JPAlbert Einstein College of Medicine · USSystems Control (United States) · US

Funding

SUPPORT FOR THE ROSE F KENNEDY IDDRC P50P50HD105352 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Julie Secombe · 2021 to 2026
$7.0M
Coordination of molecular motor activity in intracellular transport and assembly of cytoskeletal architecture.R35GM124889 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Richard James McKenney · 2017 to 2026
$4.3M
Role of the Kinesin KIF1A in Neurological DiseaseR01NS114636 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CHUNG, WENDY K, GENNERICH, ARNE · 2020 to 2024
$3.2M
NICHD NIH HHS P50 HD105352NIGMS NIH HHS R35 GM124889NINDS NIH HHS R01 NS114636
6 · The paper itself

Abstract

KIF1A is a critical cargo transport motor within neurons. More than 100 known mutations result in

Indexed as

KinesinsMicrotubulesChildHumansMutationMutation, MissenseNeuronsKIF1A protein, humanKinesins

Identifiers

PMID33931448
PMCPMC8087401
OpenAlexW3159770098

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.