Evidence map›Paper›PMID 33931406›Full record

ArticleBMJ open2021

Evaluation of qPCR on blood and skin microbiopsies, peripheral blood buffy coat smear, and urine antigen ELISA for diagnosis and test of cure for visceral leishmaniasis in HIV-coinfected patients in India: a prospective cohort study.

Sophie I Owen, Sakib Burza, Shiril Kumar, Neena Verma, Raman Mahajan, Amit Harshana, Krishna Pandey, Kristien Cloots, Emily Adams, Pradeep Das

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Sophie I OwenDepartment of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, UK.ORCID 0000-0002-0458-2357
Sakib BurzaMédecins Sans Frontières, New Delhi, India.ORCID 0000-0002-3410-8541
Shiril KumarDepartment of Health Research, Rajendra Memorial Research Institute of Medical Sciences, Patna, Bihar, India.
Neena VermaDepartment of Health Research, Rajendra Memorial Research Institute of Medical Sciences, Patna, Bihar, India.
Raman MahajanMédecins Sans Frontières, New Delhi, India.ORCID 0000-0001-6788-2835
Amit HarshanaMédecins Sans Frontières, New Delhi, India.
Krishna PandeyDepartment of Health Research, Rajendra Memorial Research Institute of Medical Sciences, Patna, Bihar, India.ORCID 0000-0001-5930-2458
Kristien ClootsDepartment of Public Health, Institute of Tropical Medicine, Antwerpen, Belgium.
Emily AdamsDepartment of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, UK emily.adams@lstmed.ac.uk.
Pradeep DasDepartment of Health Research, Rajendra Memorial Research Institute of Medical Sciences, Patna, Bihar, India.
Rajendra Memorial Research Institute of Medical Sciences · INMédecins Sans Frontières‎ · GBLiverpool School of Tropical Medicine · GBResearch Institute for Tropical Medicine · PH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHIV coinfection presents a challenge for diagnosis of visceral leishmaniasis (VL). Invasive splenic or bone marrow aspiration with microscopic visualisation of METHODS AND ANALYSIS: We aim to evaluate blood and skin qPCR, peripheral blood buffy coat smear microscopy and urine antigen ELISA as non-invasive or minimally invasive alternatives for diagnosis and post-treatment test of cure for VL in HIV-coinfected patients in India, using a sample of 91 patients with parasitologically confirmed symptomatic VL-HIV infection. ETHICS AND DISSEMINATION: Ethical approval for this study has been granted by The Liverpool School of Tropical Medicine, The Institute of Tropical Medicine in Antwerp, the University of Antwerp and the Rajendra Memorial Research Institute of Medical Science in Patna. Any future publications will be published in open access journals. TRIAL REGISTRATION NUMBER: CTRI/2019/03/017908.

Indexed as

CoinfectionHIV InfectionsLeishmaniasis, VisceralBlood Buffy CoatEnzyme-Linked Immunosorbent AssayHumansIndiaProspective StudiesSensitivity and SpecificityHIV & AIDSmolecular diagnosticsparasitologythoracic medicinetropical medicine

Identifiers

PMID33931406
PMCPMC8098939
OpenAlexW3159763068

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.