ArticleEye and vision (London, England)2021
Long term results of accelerated 9 mW corneal crosslinking for early progressive keratoconus: the Siena Eye-Cross Study 2.
Article in Eye and vision (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 76 citations in OpenAlex.
- A randomised controlled trial on cross-linking protocols for the treatment of progressive keratoconus using isoosmolar and hypoosmolar riboflavin with the addition of sterile water in thin corneae.Acta ophthalmologica · 2026Trial
- Early findings in a prospective randomised study on three cross-linking treatment protocols: interruption of the iontophoresis treatment protocol.BMJ open ophthalmology · 2023Trial
- The Science and Clinical Evolution of Corneal Cross-Linking: Mechanism of Action, Ultra-Structural Changes, Clinical Indications, and Emerging Treatment Strategies.Ophthalmology and therapy · 2026Review
- Paediatric Keratoconus: An ERN-EYE Clinical Consensus Statement on Diagnosis, Treatment and Follow-Up Care.Ophthalmology and therapy · 2026Review
- [Cross-linking treatment of ultrathin corneas: the ELZA-sub400 protocol : Individualized adaptation of fluence as paradigm shift in CXL treatment of thin corneal conditions].Die Ophthalmologie · 2026Review
- Regional Biomechanical and Topographic Changes after Transepithelial vs. Epithelium-off Continuous Accelerated Corneal Cross-linking in Keratoconus: Updated Stress-Strain Index as a Superior Biomarker.Ophthalmology science · 2026Article
- [Light-induced immunomodulation : Corneal cross-linking to reduce neovascularization and optimize outcomes prior to corneal transplantation].Die Ophthalmologie · 2026Review
- One-Year Comparative Outcomes of Conventional Versus Accelerated Corneal Cross-Linking in Progressive Keratoconus.Medicina (Kaunas, Lithuania) · 2026Article
- Review
- Transepithelial corneal cross-linking: a review.International ophthalmology · 2026Review
- Differential dose-response relationships of collagen cross-linking in the cornea and sclera.Frontiers in bioengineering and biotechnology · 2026Article
- Comparison of conventional corneal crosslinking with the accelerated procedure in progressive keratoconus.International ophthalmology · 2025Article
- Comparison of corneal pachymetry evolution after accelerated corneal crosslinking in keratoconus eyes using anterior segment optical coherence tomography and Scheimpflug imaging.International ophthalmology · 2025Article
- Crosslinking for post refractive surgery ectasia: application and clinical outcomes.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Long-term outcomes after high-energy accelerated pulsed corneal cross-linking (15 mW/cmInternational ophthalmology · 2025Article
- Predicting the Effects of Customized Corneal Cross-Linking on Corneal Geometry.Investigative ophthalmology & visual science · 2025Article
- Long-term Effects and Prognostic Factors of Accelerated Cross-Linking with Retention Ring-assisted Riboflavin Application on Keratoconus Progression.Korean journal of ophthalmology : KJO · 2025Article
- Efficacy and Safety of Accelerated Transepithelial Corneal Crosslinking in Non-Pediatric Patients with Progressive Keratoconus: Insights from a Retrospective Cohort Study.Healthcare (Basel, Switzerland) · 2025Article
- CTK-like syndrome: Corneal opacity and flattening following sequential intracorneal ring implantation and corneal cross-linking.American journal of ophthalmology case reports · 2024Article
- Determining the Relationship Between Corneal Stiffening and Tissue Dehydration After Corneal Cross-Linking.Investigative ophthalmology & visual science · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess clinical results of the 9 mW/5.4 J/cm
methodsThe prospective open non-randomized interventional study (Siena Eye-Cross Study 2) included 156 eyes of 112 patients with early progressive KC undergoing the Epi-Off 9 mW/5.4 J/cm
resultsUDVA and CDVA improved significantly at the 3rd (P = 0.028), Δ + 0.17 Snellen lines and 6th postoperative month, respectively (P < 0.001), Δ + 0.23 Snellen lines. Kmax improved at the 6th postoperative month (P = 0.03), Δ - 1.49 diopters from the baseline value. Also, coma aberration value improved significantly (P = 0.004). A mild temporary haze was recorded in 14.77% of patients without affecting visual acuity and without persistent complications. Corneal OCT revealed a mean demarcation line depth at 332.6 ± 33.6 μm.
conclusionThe 5-year results of Epi-Off 9 mW/5.4 J/cm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.