Evidence map›Paper›PMID 33931029›Full record

ArticleBMC pediatrics2021

Updated analysis of pediatric clinical studies registered in ClinicalTrials.gov, 2008-2019.

Yang Zhong, Xingyu Zhang, Lijun Zhou, Lei Li, Tao Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yang Zhong *Department of Epidemiology and Health Statistics, West China School of Public Health and West China fourth Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Xingyu Zhang *Department of Systems, Populations and Leadership, University of Michigan School of Nursing, Ann Arbor, MI, USA.
Lijun ZhouSichuan Center for Disease Control and Prevention, Chengdu, Sichuan Province, China.
Lei LiDepartment of Anesthesiology, Chengdu Women's and Children's Central Hospital,School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China.
Tao ZhangDepartment of Epidemiology and Health Statistics, West China School of Public Health and West China fourth Hospital, Sichuan University, Chengdu, Sichuan Province, China. statzhangtao@scu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSince the national clinical trials registry ( ClinicalTrials.gov ) launched in February 2000, more than 360,000 research studies in the United States and over 200 countries have registered. As the characteristics of pediatric clinical studies keep changing over time and the results-reporting mechanism is under evolving, to know about the relevant updates of data elements and the effect of policies on the quality of reporting results is significant.

methodsIn this research, 53,060 clinical studies related to children registered from January 2008 to December 2019 were downloaded from ClinicalTrials.gov on August 1st, 2020. Different types of studies and critical categorical variables were identified, based on which, Cochran-Armitage test was performed to explore temporal trend of study characteristics and common pediatric clinical conditions in four time subsets. Further, to examine heterogeneity among subgroups (funding sources, funding sites, pediatric clinical conditions,etc), chi-squared test was applied.

resultsA total of 36,136 clinical trials and 16,692 observational studies were identified during the study period. The pediatric clinical trials increased from 7,029 (January 2008-December 2010) to 11,738 (January 2017-December 2019). The number of missing data has declined, with the maximum extent decline from 3.7 to 0.0% (Z = - 15.90, p <  0.001). Drug trials decreased from 48.8 to 28.9% (Z = - 24.68, p <  0.001). Behavioral trials, on the other hand, increased from 12.6 to 20.4% (Z = 12.28, p <  0.001). Most pediatric clinical trials were small-scale (58.9% enrolling 1-100 participants), single-site (61.4%) and funded neither by industry nor by the NIH (59.2%). The proportion of reporting study results varied by study type (χ

conclusionPediatric clinical studies registered in ClinicalTrials.gov were dominated by small-scale interventional trials, containing significant heterogeneity in funding sources, funding sites, pediatric clinical conditions and study characteristics. Although the results database has evolved in the past decade, efforts to strengthen the practice of systematic reporting must be continued.

Indexed as

Research DesignChildChi-Square DistributionDatabases, FactualHumansRegistriesUnited StatesClinical trialsClinicalTrials.govPediatricsTrial registries

Identifiers

PMID33931029
PMCPMC8086350

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.