Evidence map›Paper›PMID 33931018›Full record

ArticleBMC pediatrics2021

Vitamin D deficiency in children with acute bronchiolitis: a prospective cross-sectional case- control study.

Inbal Golan-Tripto, Neta Loewenthal, Asher Tal, Yotam Dizitzer, Yael Baumfeld, Aviv Goldbart

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05795933 (Efficacy of Vitamin D Supplementation for Children With Bronchiolitis at Sohag University Hospital), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05795933 phase2 / phase3completednot on this mapstarted 2023, after this paper: background citation

Efficacy of Vitamin D Supplementation for Children With Bronchiolitis at Sohag University Hospital

TypeinterventionalSponsorSohag UniversityRan2023 to 2024Enrolled146ConditionsBronchiolitisArmsVitamin D3
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Inbal Golan-TriptoDepartment of Pediatrics, Soroka University Medical Center, Beer-Sheva, Israel. inbalgt@clalit.org.il.
Neta LoewenthalDepartment of Pediatrics, Soroka University Medical Center, Beer-Sheva, Israel.
Asher TalFaculty of Health Sciences, Ben-Gurion University of the Negev, PO box 151, Beer-Sheva, Israel.
Yotam DizitzerClinical Research Center, Soroka University Medical Center, Beer Sheva, Israel.
Yael BaumfeldFaculty of Health Sciences, Ben-Gurion University of the Negev, PO box 151, Beer-Sheva, Israel.
Aviv GoldbartDepartment of Pediatrics, Soroka University Medical Center, Beer-Sheva, Israel.
Soroka Medical Center · ILBen-Gurion University of the Negev · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background25(OH) vitamin D levels are inversely associated with respiratory infections and childhood wheezing.

objectiveTo evaluate serum 25(OH) vitamin D levels in infants and toddlers with acute bronchiolitis, compared to subjects with non-respiratory febrile illness.

methodsA prospective cross-sectional case-control study which compared serum 25(OH) vitamin D levels between infants and toddlers diagnosed with acute bronchiolitis to subjects with non-respiratory febrile illness. Multivariate logistic regression, adjusted for age, sex, ethnicity and nutrition was performed. Correlation between serum vitamin D levels and bronchiolitis severity was assessed via Modified Tal Score and length of hospital stay (LOS).

resultsOne hundred twenty-seven patients aged < 24 months were recruited; 80 diagnosed with acute bronchiolitis and 47 patients with non- respiratory febrile illnesses. Both groups had similar demographics aside from age (median [IQR] 5 [3-9] vs. 9 [5-16] months in the bronchiolitis group compared to control group (p = 0.002)). Serum 25(OH) vitamin D levels were significantly lower in the bronchiolitis group; median [IQR] 28[18-52] vs. 50[25-79] nmol/L, respectively, (p = 0.005). Deficient vitamin D levels (< 50 nmol/L) was found more frequently in the bronchiolitis group than controls; 73% vs. 51% (p = 0.028). Multivariate logistic regression showed vitamin D deficiency was more probable in bronchiolitis patients; OR [95% CI] 3.139[1.369-7.195]. No correlation was found between serum vitamin D levels and bronchiolitis severity, which was assessed via Modified Tal Score and by length of hospital stay.

conclusionChildren with acute bronchiolitis displayed significantly lower vitamin D levels than children with non-respiratory acute febrile illnesses.

Indexed as

BronchiolitisVitamin D DeficiencyCase-Control StudiesChildChild, PreschoolCross-Sectional StudiesHumansInfantProspective StudiesVitamin DVitamin DBronchiolitisChildrenVitamin D deficiencyVitamin D status

Identifiers

PMID33931018
PMCPMC8085105
OpenAlexW3119873880

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.