ArticlePsychoneuroendocrinology2021
Sexually divergent cortical control of affective-autonomic integration.
Article in Psychoneuroendocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Prefrontal-medullary circuitry is necessary for sex-specific responses to metabolic stress in rats.Endocrinology · 2026Article
- Sex-specific organization and synaptic signaling in prefrontal-hypothalamic circuitry.bioRxiv : the preprint server for biology · 2026Article
- Prefrontal-medullary circuitry is necessary for sex-specific responses to metabolic stress in rats.bioRxiv : the preprint server for biology · 2026Article
- Sexual dimorphism and acute stress modulation of infralimbic-posterior hypothalamic synaptic transmission.Frontiers in cellular neuroscience · 2026Article
- Neural networks of the mouse visceromotor cortex.Nature · 2025Article
- Infralimbic prefrontal cortical projections to the autonomic brainstem: quantification of inputs to cholinergic and adrenergic/noradrenergic nuclei.Brain structure & function · 2025Article
- Revisiting sex as a biological variable in hypertension research.The Journal of clinical investigation · 2024Review
- Sex-specific cardiac remodeling in aged rats after adolescent chronic stress: associations with endocrine and metabolic factors.Biology of sex differences · 2024Article
- Sex-Specific Cardiac Remodeling in Aged Rats after Early-Life Chronic Stress: Associations with Endocrine and Metabolic Factors.bioRxiv : the preprint server for biology · 2024Article
- Cortical-brainstem circuitry attenuates physiological stress reactivity.The Journal of physiology · 2024Article
- Sex-specific prefrontal-hypothalamic control of behavior and stress responding.Psychoneuroendocrinology · 2024Article
- Prefrontal representation of affective stimuli: importance of stress, sex, and context.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Sex differences in autonomic responses to stress: implications for cardiometabolic physiology.American journal of physiology. Endocrinology and metabolism · 2022Review
- What the hippocampus tells the HPA axis: Hippocampal output attenuates acute stress responses via disynaptic inhibition of CRF+ PVN neurons.Neurobiology of stress · 2022Article
- Cortical-Hypothalamic Integration of Autonomic and Endocrine Stress Responses.Frontiers in physiology · 2022Review
- Effects of Biological Sex and Stress Exposure on Ventromedial Prefrontal Regulation of Mood-Related Behaviors.Frontiers in behavioral neuroscience · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Depression and cardiovascular disease reduce quality of life and increase mortality risk. These conditions commonly co-occur with sex-based differences in incidence and severity. However, the biological mechanisms linking the disorders are poorly understood. In the current study, we hypothesized that the infralimbic (IL) prefrontal cortex integrates mood-related behaviors with the cardiovascular burden of chronic stress. In a rodent model, we utilized optogenetics during behavior and in vivo physiological monitoring to examine how the IL regulates affect, social motivation, neuroendocrine-autonomic stress reactivity, and the cardiac consequences of chronic stress. Our results indicate that IL glutamate neurons increase socio-motivational behaviors specifically in males. IL activation also reduced endocrine and cardiovascular stress responses in males, while increasing reactivity in females. Moreover, prior IL stimulation protected males from subsequent chronic stress-induced sympatho-vagal imbalance and cardiac hypertrophy. Our findings suggest that cortical regulation of behavior, physiological stress responses, and cardiovascular outcomes fundamentally differ between sexes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.