ArticleDrug and alcohol dependence2021
Nicotine formulations impact reinforcement-related behaviors in a mouse model of vapor self-administration.
Article in Drug and alcohol dependence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
30 citing papers in PubMed.
- Synthetic cooling agents enhance nicotine reinforcement and mesolimbic dopamine signaling.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Chronic nicotine vapor-induced enhancement of ethanol drinking-in-the-dark is associated with reduced medial prefrontal cortical activity.Psychopharmacology · 2026Article
- Early life nicotine vapor exposure increases nicotine vapor seeking in adult male rats.Psychopharmacology · 2026Article
- Effects of commercial unflavored and vanilla-flavored e-liquids on nicotine intake and withdrawal.bioRxiv : the preprint server for biology · 2026Article
- 6-Methyl nicotine and nicotine have similar thermoregulatory and reinforcing effects in middle aged female rats with a history of nicotine vapor self-administration.Pharmacology, biochemistry, and behavior · 2026Article
- A novel self-inhaled nicotine exposure system in murine models reveals age-dependent metabolic effects of nicotine.Cell & bioscience · 2025Article
- Impact of chemical flavorants on reinforcement-related behavior in an adolescent mouse model of vaping self-administration.The Journal of pharmacology and experimental therapeutics · 2025Article
- The influence of high-fat diet on nicotine vapor self-administration, neuronal excitability, and leptin levels in adult mice.Physiology & behavior · 2025Article
- Age-dependent effects of vaping on the prefrontal cortex, ventral tegmental area, and nucleus accumbens.Communications biology · 2024Article
- Voluntary nicotine consumption and reward in a subset of diversity outbred founder strains.Journal of psychopharmacology (Oxford, England) · 2024Article
- Sex Differences in Response-Contingent Cannabis Vapor Administration During Adolescence Mediate Enduring Effects on Behavioral Flexibility and Prefrontal Microglia Activation in Rats.Cannabis and cannabinoid research · 2024Article
- Adult Consequences of Repeated Nicotine Vapor Inhalation in Adolescent Rats.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Article
- Factors influencing JUUL e-cigarette nicotine vapour-induced reward, withdrawal, pharmacokinetics and brain connectivity in rats: sex matters.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Adult consequences of repeated nicotine and ΔPsychopharmacology · 2024Article
- The Impact of High or Low Doses of Nicotine in a Mouse Model of Vapor Self-Administration.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Article
- Hyperactivity Induced By Vapor Inhalation of Nicotine in Male and Female Rats.bioRxiv : the preprint server for biology · 2024Article
- Article
- Development of Dependence in Smokers and Rodents With Voluntary Nicotine Intake: Similarities and Differences.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023Review
- Electronic Vaporization of Nicotine Salt or Freebase produces differential effects on metabolism, neuronal activity and behavior in male and female C57BL/6J mice.Addiction neuroscience · 2023Article
- Chemical Flavorants in Vaping Products Alter Neurobiology in a Sex-Dependent Manner to Promote Vaping-Related Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
backgroundElectronic nicotine delivery systems (ENDS) differ from combustible cigarettes given that nicotine-salt or nicotine-freebase may be used depending on the product. We have investigated how nicotine-salt and freebase formulations alter e-Vape® self-administration (EVSA) behavior and plasma cotinine levels in male and female mice.
methodsAdult C57/BL6 J mice were used in EVSA and assigned vaping e-liquids (50:50 PGVG, 6 mg/mL nicotine-freebase, or 6 mg/mL nicotine-salt). Mice were escalated on a fixed ratio 1 (FR1) schedule in daily 2 h sessions and then transitioned to a FR3 to examine reinforcement-related behaviors.
resultsHere we observed that mice assigned nicotine-salt exhibited increased EVSA on a FR3 schedule compared to nicotine-freebase. Additionally, mice assigned nicotine-salt exhibited higher plasma cotinine concentrations following delivery-controlled passive-inhalation sessions.
conclusionsThese data provide evidence nicotine-salt formulations may contribute to greater reinforcement-related behavior and highlight the need for further investigations regarding nicotine formulation in ENDS.
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