Evidence map›Paper›PMID 33930255›Full record

ArticleAngewandte Chemie (International ed. in English)2021

Redox-Responsive Gene Delivery from Perfluorocarbon Nanoemulsions through Cleavable Poly(2-oxazoline) Surfactants.

Daniel A Estabrook, Rachael A Day, Ellen M Sletten

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Non-Ionic Fluorosurfactants for Droplet-Based in vivo Applications.Angewandte Chemie (International ed. in English) · 2024
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Daniel A EstabrookDepartment of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young, Dr. E., Los Angeles, CA, 90095, USA.ORCID 0000-0001-7237-6291
Rachael A DayDepartment of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young, Dr. E., Los Angeles, CA, 90095, USA.ORCID 0000-0002-0018-7712
Ellen M SlettenDepartment of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young, Dr. E., Los Angeles, CA, 90095, USA.ORCID 0000-0002-0049-7278

Funding

Biotechnology Training in Biomedical Sciences and EngineeringT32GM067555 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GU, ZHEN · 2005 to 2019
$2.8M
NIGMS NIH HHS T32 GM067555
6 · The paper itself

Abstract

The clinical utility of emulsions as delivery vehicles is hindered by a dependence on passive release. Stimuli-responsive emulsions overcome this limitation but rely on external triggers or are composed of nanoparticle-stabilized droplets that preclude sizes necessary for biomedical applications. Here, we employ cleavable poly(2-oxazoline) diblock copolymer surfactants to form perfluorocarbon (PFC) nanoemulsions that release cargo upon exposure to glutathione. These surfactants allow for the first example of redox-responsive nanoemulsions in cellulo. A noncovalent fluorous tagging strategy is leveraged to solubilize a GFP plasmid inside the PFC nanoemulsions, whereupon protein expression is achieved selectively when employing a stimuli-responsive surfactant. This work contributes a methodology for non-viral gene delivery and represents a general approach to nanoemulsions that respond to endogenous stimuli.

Indexed as

Gene Transfer TechniquesDisulfidesDNADrug CarriersEmulsionsFluorocarbonsGlutathioneGreen Fluorescent ProteinsHEK293 CellsHumansOxidation-ReductionPlasmidsPolyaminesSurface-Active AgentsDisulfidesDNADrug CarriersEmulsionsenhanced green fluorescent proteinFluorocarbonsGlutathioneGreen Fluorescent Proteinspoly(2-methyl-2-oxazoline)PolyaminesSurface-Active Agentsemulsionsgene deliveryinterfacial chemistrypoly(2-oxazoline)stimuli-responsive carriers

Identifiers

PMID33930255
PMCPMC8319079

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.