Evidence map›Paper›PMID 33930240›Full record

ArticleAngewandte Chemie (International ed. in English)2021

Enantioselective Total Synthesis of the Archaeal Lipid Parallel GDGT-0 (Isocaldarchaeol)*.

Isaac D Falk, Bálint Gál, Ahanjit Bhattacharya, Jeremy H Wei, Paula V Welander, Steven G Boxer, Noah Z Burns

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Isaac D FalkDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Bálint GálDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Ahanjit BhattacharyaDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.
Jeremy H WeiDepartment of Earth System Science, Stanford University, Stanford, CA, 94305, USA.
Paula V WelanderDepartment of Earth System Science, Stanford University, Stanford, CA, 94305, USA.ORCID 0000-0002-9502-6902
Steven G BoxerDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.ORCID 0000-0001-9167-4286
Noah Z BurnsDepartment of Chemistry, Stanford University, Stanford, CA, 94305, USA.ORCID 0000-0003-1064-4507

Funding

Biophysical Studies of Macromolecules and Molecular AssembliesR35GM118044 · NIGMS · STANFORD UNIVERSITY · PI STEVEN G. BOXER · 2016 to 2026
$7.2M
NIGMS NIH HHS GM118044NIGMS NIH HHS R35 GM118044
6 · The paper itself

Abstract

Archaeal glycerol dibiphytanyl glycerol tetraethers (GDGT) are some of the most unusual membrane lipids identified in nature. These amphiphiles are the major constituents of the membranes of numerous Archaea, some of which are extremophilic organisms. Due to their unique structures, there has been significant interest in studying both the biophysical properties and the biosynthesis of these molecules. However, these studies have thus far been hampered by limited access to chemically pure samples. Herein, we report a concise and stereoselective synthesis of the archaeal tetraether lipid parallel GDGT-0 and the synthesis and self-assembly of derivatives bearing different polar groups.

Indexed as

ArchaeaGlyceryl EthersMembrane LipidsStereoisomerismGlyceryl EthersMembrane Lipidsarchaeal lipidsasymmetric hydrogenationmacrolactonizationtotal synthesis

Identifiers

PMID33930240
PMCPMC12103258

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.