Observational studyPM & R : the journal of injury, function, and rehabilitation2022
Investigating whole-brain metabolite abnormalities in the chronic stages of moderate or severe traumatic brain injury.
Observational study in PM & R : the journal of injury, function, and rehabilitation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Associations Between Brain Metabolites Measured With MR Spectroscopy and Head Impacts in High School American Football Athletes.Journal of magnetic resonance imaging : JMRI · 2025Article
- Brain metabolites are associated with sleep architecture and cognitive functioning in older adults.Brain communications · 2024Article
- Neurometabolite alterations in traumatic brain injury and associations with chronic pain.Frontiers in neuroscience · 2023Article
- ILBInternational journal of molecular sciences · 2022Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundEvidence suggests that neurometabolic abnormalities can persist after traumatic brain injury (TBI) and drive clinical symptoms such as fatigue and cognitive disruption. Magnetic resonance spectroscopy has been used to investigate metabolite abnormalities following TBI, but few studies have obtained data beyond the subacute stage or over large brain regions.
objectiveTo measure whole-brain metabolites in chronic stages of TBI.
designObservational study.
settingUniversity.
participantsEleven men with a moderate or severe TBI more than 12 months prior and 10 age-matched healthy controls completed whole-brain spectroscopic imaging. MAIN MEASURES: Ratios of N-acetylaspartate (NAA), choline (CHO), and myo-inositol (MI) to creatine (CR) were measured in whole-brain gray and white matter as well as 64 brain regions of interest. Arterial spin labeling (ASL) data were also collected to investigate whether metabolite abnormalities were accompanied by differences in cerebral perfusion.
resultsThere were no differences in metabolite ratios within whole-brain gray and white matter regions of interest (ROIs). Linear regression showed lower NAA/CR in the white matter of the left occipital lobe but higher NAA/CR in the gray matter of the left parietal lobe. Metabolite abnormalities were observed in several brain regions in the TBI group including the corpus callosum, putamen, and posterior cingulate. However, none of the findings survived correction for multiple comparison. There were no differences in cerebral blood flow between patients and controls.
conclusionHigher MI/CR may indicate ongoing gliosis, and it has been suggested that low CHO/CR at chronic time points may indicate cell death or lack of healthy turnover and repair. However, with the small sample size of this study, we caution against the over interpretation of our results. None of the findings within ROIs survived correction for multiple comparison. Thus, they may be considered possible avenues for future research in this area.
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