ArticlePloS one2021
Association between number of teeth and Alzheimer's disease using the National Database of Health Insurance Claims and Specific Health Checkups of Japan.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Development of a predictive model for long-term care and support eligibility certification associated with dementia-related functional impairments: the IRIDE cohort study.BMC public health · 2025Article
- Opioid prescription status around surgery, bone metastasis, or death events among patients with breast cancer in Japan: an analysis of the Japanese public health insurance comprehensive claims database (the National Database).Japanese journal of clinical oncology · 2025Article
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- Loss of dental pulp potentially increased the risk of Alzheimer's dementia.Journal of dental sciences · 2025Article
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- Validity of the self-reported number of teeth in independent older people in Japan.BMC geriatrics · 2024Article
- Longitudinal association of oral functions and dementia in Japanese older adults.Scientific reports · 2024Article
- Association Between Reduced Posterior Occlusal Contact and Alzheimer's Disease Onset in Older Japanese Adults: Results from the LIFE Study.Journal of Alzheimer's disease : JAD · 2024Article
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- Poor Oral Health Linked with Higher Risk of Alzheimer's Disease.Brain sciences · 2023Article
- Associations of Death at Home with Medical Resources and Medical Activities in Cancer Patients: A Nationwide Study Using Japanese National Database.Annals of geriatric medicine and research · 2023Article
- Disease trends afterWorld journal of gastroenterology · 2023Article
- Article
- Use of the dental formula from the National Database of Health Insurance Claims and Specific Health Checkups of Japan.The Japanese dental science review · 2022Review
- COR388 (atuzaginstat): an investigational gingipain inhibitor for the treatment of Alzheimer disease.Expert opinion on investigational drugs · 2022Article
- The Impact of Masticatory Function on Cognitive Impairment in Older Patients: A Population-Based Matched Case-Control Study.Yonsei medical journal · 2022Article
- Policies Supporting Oral Health in Ageing Populations Are Needed Worldwide.International dental journal · 2022Review
- Glycemic control and number of natural teeth: analysis of cross-sectional Japanese employment-based dental insurance claims and medical check-up data.Diabetology international · 2022Article
- Severity of Dementia Is Associated with Increased Periodontal Inflamed Surface Area: Home Visit Survey of People with Cognitive Decline Living in the Community.International journal of environmental research and public health · 2021Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Associations of numbers of teeth present and of missing teeth with Alzheimer's disease were cross-sectionally analyzed using the National Database of Health Insurance Claims and Specific Health Checkups of Japan. Dental care claims data of patients aged 60 years or older diagnosed with periodontitis (n = 4,009,345) or missing teeth (n = 662,182) were used to obtain information about the numbers of teeth present and of missing teeth, respectively, and they were combined with medical care claims data including the diagnosis of Alzheimer's disease. Numbers of teeth present and of missing teeth excluding third molars were calculated using the dental formula in the claims for periodontitis and missing teeth, respectively, and categorized into three groups each. Percentages of subjects treated for Alzheimer's disease with 20-28, 10-19, and 1-9 teeth present were 1.95%, 3.87%, and 6.86%, respectively, in patients diagnosed as having periodontitis, and those treated for Alzheimer's disease with 1-13, 14-27, and 28 missing teeth were 2.67%, 5.51%, and 8.70%, respectively, in patients diagnosed as having missing teeth. Logistic regression models using treatment for Alzheimer's disease as an outcome variable and adjusting for age and sex showed that odds ratios (95% confidence intervals) for patients with 10-19 and 1-9 teeth (reference: 20-28 teeth) were 1.11 (1.10-1.13) and 1.34 (1.32-1.37), respectively, (p<0.001), in patients diagnosed as having periodontitis, and odds ratios (95% confidence intervals) for patients with 14-27 missing teeth and 28 missing teeth (reference: 1-13 missing teeth) were 1.40 (1.36-1.44) and 1.81 (1.74-1.89), respectively, (p<0.001), in patients diagnosed as having missing teeth. In conclusion, the results of the present study using Japanese dental claims data showed that older people visiting dental offices with fewer teeth present and a greater number of missing teeth are more likely to have Alzheimer's disease.
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