ArticlePloS one2021
Achalasia is associated with a higher incidence of depression in outpatients in Germany.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Idiopathic achalasia: unraveling the etiology and pathogenesis of an inflammatory disease.Gastroenterology report · 2026Review
- Integrating psychological assessment in achalasia management: addressing mental health to enhance patient outcomes.European journal of translational myology · 2024Article
- Article
- Initial assessment of medical post-traumatic stress among patients with chronic esophageal diseases.Neurogastroenterology and motility · 2023Article
- Psychological burden of achalasia: Patients' screening rates of depression and anxiety and sex differences.PloS one · 2023Article
- Swallowing and quality of life in individuals with Marfan syndrome: a cross-sectional study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Article
- Autoimmune and viral risk factors are associated with achalasia: A case-control study.Neurogastroenterology and motility · 2022Article
- Achalasia.Nature reviews. Disease primers · 2022Review
- The role of Ivor Lewis esophagectomy in the treatment of achalasia with megaesophagus: A case report.Annals of medicine and surgery (2012) · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimAchalasia represents a chronic motility disorder of the esophagus featuring an impaired lower esophageal sphincter relaxation and loss of esophageal peristalsis. By causing dysphagia, regurgitation, aspiration and chest pain, achalasia might tremendously affect life quality of patients. However, the impact of achalasia on the development of mood disorders including depression has largely remained unclear. The aim of this study was to evaluate the incidence of depression in achalasia patients.
methodsWe analyzed a large primary care cohort database in Germany capturing data from 7.49 million patients.
resultsA total of n = 1,057 patients with achalasia diagnosed between January 2005 and December 2018 were matched to a cohort of n = 3,171 patients without achalasia controlling for age, sex, physician, index year, and the Charlson comorbidity index. Interestingly, while the frequency of depression prior to the diagnosis of achalasia was comparable in both groups, new diagnoses of depression were significantly higher within one year after the diagnosis of achalasia compared to the control group, suggesting a direct and previously unrecognized association between achalasia and depression.
conclusionOur data suggest that the clinical management of patients with achalasia should include a careful and structured work-up for mood disorders in order to improve long-term quality of life in these patients.
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