Evidence map›Paper›PMID 33929897›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2021

Deficiency of ataxia-telangiectasia mutated kinase modulates functional and biochemical parameters of the heart in response to Western-type diet.

Mary C Wingard, Suman Dalal, Paige L Shook, Rachel Myers, Barbara A Connelly, Douglas P Thewke, Mahipal Singh, Krishna Singh

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Guidelines for in vivo mouse models of myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2021
    Guideline
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Mary C WingardDepartment of Biomedical Sciences, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee.
Suman DalalDepartment of Health Sciences, East Tennessee State University, Johnson City, Tennessee.
Paige L ShookDepartment of Biomedical Sciences, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee.
Rachel MyersDepartment of Biomedical Sciences, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee.
Barbara A ConnellyDepartment of Biomedical Sciences, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee.
Douglas P ThewkeDepartment of Biomedical Sciences, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee.
Mahipal SinghDepartment of Biomedical Sciences, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee.
Krishna SinghDepartment of Biomedical Sciences, James H Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee.
East Tennessee State University · USJames H. Quillen VA Medical Center · US

Funding

Cardioprotective Role of Extracellular Ubiquitin in Myocardial Ischemia/Reperfusion Injury and Myocyte ApoptosisR15HL141947 · NHLBI · EAST TENNESSEE STATE UNIVERSITY · PI SINGH, MAHIPAL · 2018 to 2018
$425k
Gender-specific Role of ATM in the HeartR15HL156214 · NHLBI · EAST TENNESSEE STATE UNIVERSITY · PI SINGH, KRISHNA · 2021 to 2021
$423k
Osteopontin: role in myocyte apoptosis and myocardial functionI01BX002332 · VA · JAMES H QUILLEN VA MEDICAL CENTER · PI SINGH, KRISHNA · 2014 to 2017
–
Investigation of therapeutic potential of exogenous ubiquitin following myocardial ischemia/reperfusion injuryI01BX004045 · VA · JAMES H QUILLEN VA MEDICAL CENTER · PI SINGH, KRISHNA · 2019 to 2025
–
BLRD VA I01 BX002332BLRD VA I01 BX004045HHS | NIH | Office of Extramural Research, National Institutes of Health (OER) R15HL141947NHLBI NIH HHS R15 HL141947NHLBI NIH HHS R15 HL156214U.S. Department of Veterans Affairs (VA) I01BX002332U.S. Department of Veterans Affairs (VA) I01BX004045
6 · The paper itself

Abstract

Ataxia-telangiectasia mutated (ATM) kinase deficiency exacerbates heart dysfunction late after myocardial infarction. Here, we hypothesized that ATM deficiency modulates Western-type diet (WD)-induced cardiac remodeling with an emphasis on functional and biochemical parameters of the heart. Weight gain was assessed in male wild-type (WT) and ATM heterozygous knockout (hKO) mice on weekly basis, whereas cardiac functional and biochemical parameters were measured 14 wk post-WD. hKO-WD mice exhibited rapid body weight gain at

Indexed as

Diet, WesternAdenylate KinaseAnimalsApoptosisAtaxia Telangiectasia Mutated Proteinsbcl-2-Associated X ProteinCardiac OutputCardiomegalyChemokine CCL3Chemokine CCL4Chemokines, CCCollagen Type ICollagen Type I, alpha 1 ChainFibrosisGene-Environment InteractionGlucose Transporter Type 4Adenylate KinaseAtaxia Telangiectasia Mutated ProteinsAtm protein, mouseBax protein, mousebcl-2-Associated X ProteinCcl3 protein, mouseCcl4 protein, mouseChemokine CCL3Chemokine CCL4Chemokines, CCCollagen Type ICollagen Type I, alpha 1 ChainGlucose Transporter Type 4IFNG protein, mouseI-kappa B KinaseInterferon-gammaInterleukin-12Matrix Metalloproteinase 2Matrix Metalloproteinase 9Mmp2 protein, mouseMmp9 protein, mouseParp1 protein, mousePoly (ADP-Ribose) Polymerase-1Slc2a4 protein, mouseTOR Serine-Threonine KinasesapoptosisATMfibrosisheartWestern-type diet

Identifiers

PMID33929897
PMCPMC8289354
OpenAlexW3157677480

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.