Evidence map›Paper›PMID 33929771›Full record

ReviewAdvanced materials (Deerfield Beach, Fla.)2021

Engineering Hydrogel-Based Biomedical Photonics: Design, Fabrication, and Applications.

Carlos F Guimarães, Rajib Ahmed, Alexandra P Marques, Rui L Reis, Utkan Demirci

Abstract readReview
In one paragraph

Review in Advanced materials (Deerfield Beach, Fla.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. NIR Phosphorescent Oxygen Sensors in Natural Hydrogel Matrices.bioRxiv : the preprint server for biology · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
  20. Tough Hydrogels for Load-Bearing Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Carlos F Guimarães3B's Research Group - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimarães, Portugal.ORCID https://orcid.org/0000-0001-8235-0597
Rajib AhmedBio-Acoustic MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford for Cancer Early Detection Department of Radiology, Stanford School of Medicine, Palo Alto, CA, 94304, USA.
Alexandra P Marques3B's Research Group - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimarães, Portugal.
Rui L Reis3B's Research Group - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Guimarães, Portugal.
Utkan DemirciBio-Acoustic MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford for Cancer Early Detection Department of Radiology, Stanford School of Medicine, Palo Alto, CA, 94304, USA.ORCID https://orcid.org/0000-0003-3229-8596

Funding

UCSF-Stanford Center of Excellence in Regulatory Science and InnovationU01FD005978 · FDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ALTMAN, RUSS BIAGIO, GIACOMINI, KATHLEEN M · 2016 to 2025
$34.5M
Ultrasensitive HIV viral load quantitation using designer DNA nanostructure capture probes and photonic resonator interference scattering microscopyR01AI159454 · NIAID · STANFORD UNIVERSITY · PI CUNNINGHAM, BRIAN T., DEMIRCI, UTKAN · 2021 to 2025
$3.6M
Platform technology for detection of cancer-associated viruses in HIV patientsR01DE024971 · NIDCR · STANFORD UNIVERSITY · PI DEMIRCI, UTKAN, KAYE, KENNETH M · 2015 to 2019
$2.1M
Exosome separation and digital resolution detection of blood-based nucleic acid biomarkers for noninvasive therapeutic diagnostics in cancerR01EB029805 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI CUNNINGHAM, BRIAN T., DEMIRCI, UTKAN · 2020 to 2023
$2.1M
Portable Nanostructured Photonic Crystal Device for HIV-1 Viral LoadR01AI120683 · NIAID · STANFORD UNIVERSITY · PI CUNNINGHAM, BRIAN T., DEMIRCI, UTKAN · 2016 to 2019
$1.5M
FDA HHS U01 FD005978Fundação Luso-Americana para o DesenvolvimentoFundação para a Ciência e Tecnologia PD/BD/135253/2017NCATS NIH HHSNIAID NIH HHS R01 AI120683NIAID NIH HHS R01 AI159454NIBIB NIH HHS R01 EB029805NIDCR NIH HHS R01 DE024971NIH HHS R01 AI120683NIH HHS R01 DE024971NIH HHS R01 EB029805NIH HHS U01FD005978Stanford Clinical and Translational Science AwardStanford RISE COVID-19 Crisis Response Faculty Seed Grant Program
6 · The paper itself

Abstract

Light guiding and manipulation in photonics have become ubiquitous in events ranging from everyday communications to complex robotics and nanomedicine. The speed and sensitivity of light-matter interactions offer unprecedented advantages in biomedical optics, data transmission, photomedicine, and detection of multi-scale phenomena. Recently, hydrogels have emerged as a promising candidate for interfacing photonics and bioengineering by combining their light-guiding properties with live tissue compatibility in optical, chemical, physiological, and mechanical dimensions. Herein, the latest progress over hydrogel photonics and its applications in guidance and manipulation of light is reviewed. Physics of guiding light through hydrogels and living tissues, and existing technical challenges in translating these tools into biomedical settings are discussed. A comprehensive and thorough overview of materials, fabrication protocols, and design architectures used in hydrogel photonics is provided. Finally, recent examples of applying structures such as hydrogel optical fibers, living photonic constructs, and their use as light-driven hydrogel robots, photomedicine tools, and organ-on-a-chip models are described. By providing a critical and selective evaluation of the field's status, this work sets a foundation for the next generation of hydrogel photonic research.

Indexed as

AnimalsBiocompatible MaterialsCell Culture TechniquesDrug Delivery SystemsElastic TissueEquipment and SuppliesHumansHydrogelsOptics and PhotonicsPrinting, Three-DimensionalSurface PropertiesTissue EngineeringBiocompatible MaterialsHydrogels3D printinghydrogel photonicslight-driven robotsmulti-responsive hydrogelsoptical sensingorgan-on-chipphotomedicine

Identifiers

PMID33929771
PMCPMC8647870

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.